Detailed information NTG0506373

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: I2433_RS05450
• Genome accession: NZ_CP065056
• Coordinates: 1119450..1120760 (-)
• Length: 436 a.a.
• NCBI ID: WP_012515549.1
• Uniprot ID: A0AAW3GN95
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ14
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1117918..1119315	1119450..1120760	flank	135

Gene organization within MGE regions

Location: 1117918..1120760

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I2433_RS05445 (JDBNIEOD_01091)	-	1117918..1119315 (+)	1398	WP_206151901.1	ISNCY-like element ISSeq2 family transposase	-
I2433_RS05450 (JDBNIEOD_01092)	ciaH	1119450..1120760 (-)	1311	WP_012515549.1	HAMP domain-containing sensor histidine kinase	Regulator

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 49574.22 Da
• Isoelectric Point: 9.6507

>NTDB_id=506373 I2433_RS05450 WP_012515549.1 1119450..1120760(-) (ciaH) [Streptococcus equi subsp. zooepidemicus strain SEZ14]
MNKLKKGLLSDNYTHFFHFFAIFTGIFVVMTIIILQIMRFSVYSTVDSSLISVGQNASNYANRTMARISSFYFDAENNLI
QALPELEASKSLGSSTTNMDIILFSANGTILNSFDAFSNYQSFRLDKSQLNNIVTTQLMNFYGQKEKYHTLTVKVHIKNY
PAVAYMMAVVNVQQLDTANERYEQIIIMVMIVFWLISILASIYLAKWSRKPIMESYAKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILDNSEHIASSLDEVRNMRILTTNLLNLARRDDGIKPQLVDVDAAFFDTVFENYQLVAEESGKQFISAN
QINRPLKTDKALLKQLMTILFDNAIKYTDHNGVVEVKVRTTDKHLLISVIDNGPGIKDDDKKKIFDRFYRVDKARTRQKG
GFGLGLALAQQIVTSLKGTITVSDNKPTGAIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=506373 I2433_RS05450 WP_012515549.1 1119450..1120760(-) (ciaH) [Streptococcus equi subsp. zooepidemicus strain SEZ14]
ATGAATAAACTAAAAAAAGGATTATTGTCCGATAATTATACGCATTTTTTTCATTTCTTTGCTATTTTTACAGGCATTTT
TGTTGTCATGACCATCATTATTTTGCAAATCATGAGGTTTAGTGTCTATTCCACAGTAGACAGCAGTCTCATTTCGGTTG
GTCAAAATGCCAGCAACTATGCTAATAGGACCATGGCGAGAATATCTTCCTTTTATTTTGATGCAGAAAATAACCTTATT
CAGGCTCTTCCTGAACTGGAAGCGTCAAAATCACTTGGCTCCTCCACCACTAATATGGATATTATTTTATTTAGTGCTAA
TGGGACGATATTGAACTCCTTTGACGCTTTCTCTAATTACCAAAGCTTTCGTTTAGACAAAAGCCAGCTCAATAACATTG
TCACAACACAGCTGATGAATTTTTATGGGCAAAAGGAGAAATACCATACCCTAACTGTTAAGGTTCACATTAAAAACTAT
CCAGCAGTGGCTTATATGATGGCAGTGGTTAATGTTCAGCAGCTGGATACTGCTAATGAGCGCTATGAACAGATTATTAT
CATGGTTATGATTGTCTTTTGGTTAATTTCGATTTTGGCCAGTATTTATTTGGCTAAGTGGAGCAGAAAGCCAATTATGG
AGAGCTATGCCAAGCAAAAAATGTTTGTAGAAAATGCCAGTCATGAGCTTAGGACTCCTTTAGCGGTGCTGCAAAATCGT
TTGGAATCGCTGTTTAGAAAGCCTAACGAAACCATTTTAGACAATAGCGAGCATATTGCGTCAAGCCTAGATGAGGTTCG
TAATATGAGAATATTAACAACTAATCTGTTAAATTTAGCCAGACGTGATGATGGGATCAAGCCGCAGCTAGTTGATGTTG
ATGCAGCCTTTTTTGATACTGTTTTTGAAAACTATCAATTGGTTGCAGAAGAATCAGGCAAGCAGTTTATCTCAGCTAAT
CAGATCAATAGGCCCTTAAAGACAGATAAGGCCTTACTAAAGCAGCTGATGACCATTTTGTTTGATAACGCGATCAAATA
CACTGATCATAACGGTGTGGTTGAGGTCAAGGTTAGAACGACTGATAAGCATTTATTGATTTCTGTTATTGATAATGGCC
CAGGGATCAAGGATGATGATAAGAAAAAGATTTTTGATCGCTTTTACCGAGTGGATAAGGCAAGGACACGCCAAAAAGGA
GGCTTTGGACTCGGATTGGCCTTAGCGCAACAGATCGTCACCTCATTAAAAGGAACGATTACTGTCAGCGATAATAAGCC
TACCGGCGCTATTTTTGAGGTAAAATTATAG

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.376	100	0.514
ciaH	Streptococcus pneumoniae D39	51.376	100	0.514
ciaH	Streptococcus pneumoniae R6	51.376	100	0.514
ciaH	Streptococcus pneumoniae TIGR4	51.376	100	0.514