Detailed information NTG0050466

Bioinformatically predicted

Overview

• Name: comD/blpH
• Type: Regulator
• Locus tag: SCRE_RS10580
• Genome accession: NC_022236
• Coordinates: 556399..557220 (-)
• Length: 273 a.a.
• NCBI ID: WP_235043796.1
• Uniprot ID: -
• Organism: Streptococcus constellatus subsp. pharyngis C232
• Function: phosphorylation of ComE; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 551399..562220

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCRE_RS02825 (SCRE_0558)	-	551729..552103 (-)	375	WP_022525583.1	hypothetical protein	-
SCRE_RS02830 (SCRE_0559)	comA/nlmT	552587..554737 (+)	2151	WP_006267089.1	peptide cleavage/export ABC transporter	Regulator
SCRE_RS02835 (SCRE_0560)	-	554748..556108 (+)	1361	Protein_545	bacteriocin secretion accessory protein	-
SCRE_RS02840 (SCRE_0561)	-	556205..556354 (+)	150	WP_003037249.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCRE_RS10580	comD/blpH	556399..557220 (-)	822	WP_235043796.1	sensor histidine kinase	Regulator
SCRE_RS02850 (SCRE_0563)	comE/blpR	557711..558457 (-)	747	WP_041786327.1	response regulator transcription factor	Regulator
SCRE_RS02855 (SCRE_0564)	-	558626..559339 (-)	714	WP_020997680.1	CPBP family intramembrane glutamic endopeptidase	-
SCRE_RS02860 (SCRE_0565)	-	559571..559792 (+)	222	WP_006267535.1	Blp family class II bacteriocin	-
SCRE_RS02870 (SCRE_0567)	-	560469..560789 (+)	321	WP_006267159.1	hypothetical protein	-
SCRE_RS02875 (SCRE_0568)	-	560797..561030 (+)	234	WP_003025420.1	garvicin Q family class II bacteriocin	-
SCRE_RS02880 (SCRE_0569)	-	561082..561372 (+)	291	WP_006267076.1	bacteriocin immunity protein	-
SCRE_RS02885 (SCRE_0570)	-	561522..561842 (+)	321	WP_006267110.1	hypothetical protein	-

Sequence

Protein

• Length: 273 a.a.
• Molecular weight: 31282.82 Da
• Isoelectric Point: 6.1166

>NTDB_id=50466 SCRE_RS10580 WP_235043796.1 556399..557220(-) (comD/blpH) [Streptococcus constellatus subsp. pharyngis C232]
MIVYHLIVQVLSYLENESNIQTLNFRESLVVLYLILFVSVANYLDRHLRERIQNDLMLQKDLQLKNMENYSHHIEELYTE
VRSFRHDYANILTTLKLGIEQNDIGIVKNVYHSVLKDSNKRFRNPKYDIGRLVHIKNDALKSLLAAKFAQAQEHNVSVSL
EVPEDICPQGMELIDFITIVSILCDNAIEATTPTMTIAYVLSENKQVFSIENAIKEEHIDMSYIFDAGVSSKGSGRGIGL
SNVLAILDRYPNVSLTSASQNYRFQHVLEIHLN

Nucleotide

• Length: 822 bp

>NTDB_id=50466 SCRE_RS10580 WP_235043796.1 556399..557220(-) (comD/blpH) [Streptococcus constellatus subsp. pharyngis C232]
ATGATTGTTTATCATCTTATTGTTCAAGTTCTATCTTATTTAGAAAACGAGAGTAACATACAGACACTAAATTTTAGAGA
AAGTTTAGTAGTTCTTTATCTTATCCTTTTTGTGAGTGTTGCCAATTATTTAGACCGTCATTTACGAGAGAGAATCCAAA
ATGATTTAATGCTTCAAAAAGATTTACAGTTAAAAAATATGGAAAACTACAGTCATCACATTGAGGAATTGTACACAGAA
GTTCGGAGCTTTCGGCATGATTACGCTAATATTTTAACAACCTTGAAATTAGGAATTGAGCAAAATGATATAGGCATTGT
AAAGAATGTCTATCATTCTGTTTTGAAAGATTCCAATAAGCGTTTTCGCAATCCCAAGTATGATATTGGACGGTTAGTCC
ATATCAAAAACGATGCCTTAAAAAGCCTGCTAGCTGCTAAATTTGCACAAGCTCAAGAGCATAATGTATCCGTTTCATTG
GAGGTTCCAGAAGATATTTGTCCACAAGGAATGGAATTAATTGACTTTATCACCATTGTCTCCATTTTGTGTGATAATGC
GATTGAAGCTACCACTCCAACTATGACGATTGCTTATGTTTTGTCAGAAAACAAGCAGGTATTCTCCATTGAAAATGCTA
TAAAAGAAGAGCATATAGACATGTCTTATATTTTTGATGCGGGAGTTAGTTCTAAAGGATCTGGGCGAGGAATTGGATTA
TCAAATGTCTTAGCAATTCTGGATCGATATCCAAATGTTTCTCTTACTAGCGCTAGTCAAAATTATCGTTTCCAGCATGT
CCTTGAGATTCATCTGAATTAA

Domains

Predicted by InterProScan.

• GHKL domain (HATPase_c_5) (171-266)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/blpH	Streptococcus mutans UA159	43.796	100	0.44
comD/comD3	Streptococcus equinus JB1	41.107	92.674	0.381
comD/comD2	Streptococcus equinus JB1	37.681	100	0.381