Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SCRE_RS09240 Genome accession   NC_022236
Coordinates   1838306..1840252 (-) Length   648 a.a.
NCBI ID   WP_020998097.1    Uniprot ID   U2XXQ8
Organism   Streptococcus constellatus subsp. pharyngis C232     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1833306..1845252
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCRE_RS09215 (SCRE_1800) - 1834538..1834807 (-) 270 WP_020998096.1 hypothetical protein -
  SCRE_RS09220 (SCRE_1801) - 1835190..1836044 (+) 855 WP_006269187.1 Rgg/GadR/MutR family transcriptional regulator -
  SCRE_RS09225 (SCRE_1802) - 1836205..1836618 (+) 414 WP_006269778.1 EamA family transporter -
  SCRE_RS09230 (SCRE_1803) - 1836756..1837319 (-) 564 WP_006269031.1 DNA-3-methyladenine glycosylase I -
  SCRE_RS09235 (SCRE_1804) ruvA 1837330..1837920 (-) 591 WP_006269179.1 Holliday junction branch migration protein RuvA Machinery gene
  SCRE_RS09240 (SCRE_1805) hexB 1838306..1840252 (-) 1947 WP_020998097.1 DNA mismatch repair endonuclease MutL Machinery gene
  SCRE_RS09245 (SCRE_1806) - 1840511..1840939 (+) 429 WP_006269102.1 LytTR family DNA-binding domain-containing protein -
  SCRE_RS09250 (SCRE_1807) - 1840936..1841394 (+) 459 WP_020998098.1 DUF3021 domain-containing protein -
  SCRE_RS09255 (SCRE_1808) hexA 1841535..1844093 (-) 2559 WP_020998099.1 DNA mismatch repair protein MutS Machinery gene
  SCRE_RS09260 (SCRE_1809) argR 1844256..1844696 (-) 441 WP_003071513.1 arginine repressor -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73362.53 Da        Isoelectric Point: 5.1034

>NTDB_id=50459 SCRE_RS09240 WP_020998097.1 1838306..1840252(-) (hexB) [Streptococcus constellatus subsp. pharyngis C232]
MSKIIELPENLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEVGLKSIQVIDNGEGIEHEEVSLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSRLTIETATNGGTHGTRLIAQGGEIETVEPSSCPKGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDMINRLSLAHPEVAFILLNDGKELTRTAGTGNLRQAIAGIYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEQDLIPDALENLAKSTINRANKSEQTSLPLKENRLYYDKERNDFFVRPQVSESNLPFEENATFDQQHTDTDML
ASRAVSVKFAARQTPSYDQLDHPELDQSSLERALDKLDGEETSTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYREKIGDVDDSQQQLLVPYIFEFPADDMLRLKQRMNLLEEVGVFLDEYGSNQFILREYPIWMKEEEIESGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDNDSARDLIFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=50459 SCRE_RS09240 WP_020998097.1 1838306..1840252(-) (hexB) [Streptococcus constellatus subsp. pharyngis C232]
ATGTCAAAAATTATAGAATTACCAGAAAATCTTGCTAATCAGATTGCGGCTGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAGAATTCCATTGATGCTGGTGCCACTCAAATTATAGTTGAGATTGAAGAAGTAGGGCTCAAGA
GTATTCAAGTCATCGATAATGGTGAAGGAATTGAGCATGAGGAGGTTTCCTTGGCTTTGCGGCGGCACGCAACGAGTAAA
ATTAAGAAGCAAGCCGATCTTTTTCGGATTCGGACTTTAGGCTTTCGTGGTGAAGCGCTTCCGTCTATTGCTTCTGTTTC
ACGCTTGACAATTGAAACTGCGACAAATGGTGGAACACATGGGACGCGTTTAATTGCTCAGGGGGGAGAAATTGAAACTG
TGGAACCAAGTAGTTGCCCTAAGGGTACCAAAATCAAAGTGGAAGACCTTTTTTTCAACACGCCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCAGAACTATCTCACATTGTAGATATGATTAACCGTTTGAGCTTAGCTCATCCAGAGGTCGCTTT
TATCTTGCTCAATGATGGTAAAGAGTTGACTCGGACAGCAGGAACAGGAAATTTGCGTCAAGCAATTGCTGGTATCTATG
GATTAACAACAGCAAAAAAAATGATTGAAATTTCAGCTTCTAATTTGGATTTTGAAGTATCAGGCTATATTAGTCTACCA
GAGTTGACGCGTGCCAATCGTAACTACATCACCATTCTCATCAATGGTCGTTACATCAAGAACTTCCTGCTCAATCGAGC
TATTCTTGATGGTTACGGTAGTAAGCTCATGGTTGGGCGATTCCCGATTGCTGTGATTGCTATCCAGATTGATCCTTACC
TTGCGGATGTTAATGTTCATCCGACCAAGCAAGAAGTGCGGATTTCCAAGGAGCGAGAACTGATGGTCTTGATTTCGCAA
GCTATTGCTGCGAGTTTAAAAGAACAGGATTTGATTCCGGATGCTTTGGAGAATTTAGCAAAATCAACCATTAACAGAGC
AAATAAGTCGGAGCAGACGAGCCTTCCGCTCAAAGAAAACCGACTCTATTATGACAAAGAGAGAAATGACTTTTTTGTTA
GACCTCAAGTATCAGAAAGCAATCTTCCTTTTGAGGAAAATGCTACATTTGATCAGCAGCATACTGATACAGATATGCTT
GCTTCCAGAGCAGTTTCTGTCAAATTTGCAGCAAGGCAAACTCCTTCTTACGATCAACTAGATCATCCAGAACTGGATCA
GTCAAGCTTAGAAAGAGCTTTAGATAAGTTAGATGGAGAAGAAACTTCAACTTTTCCAGAACTGGAATATTTCGGGCAAA
TGCATGGCACGTACCTCTTTGCACAAGGAAATGGTGGTCTCTATATTATCGACCAGCATGCAGCGCAGGAGCGAGTCAAA
TATGAGTATTATCGGGAAAAAATCGGTGATGTGGATGACAGTCAGCAGCAACTTTTGGTTCCCTATATCTTTGAATTTCC
AGCGGACGATATGCTGCGGCTCAAGCAGCGGATGAATCTGCTGGAAGAAGTCGGAGTTTTCTTGGACGAATACGGCAGCA
ATCAGTTTATTCTGAGGGAATACCCTATCTGGATGAAGGAAGAGGAAATCGAGTCGGGTATCTATGAGATGTGTGATATG
CTGCTCCTTACCAAGGAAGTTTCTATCAAGAAATACCGAGCTGAACTAGCGATTATGATGAGTTGCAAACGCTCTATTAA
GGCCAATCATAGCTTAGATAATGATTCGGCACGTGATTTGATCTTCCAGTTATCGCAATGTGACAATCCCTACAATTGCC
CTCACGGTCGTCCAGTTTTGGTAAACTTTACCAAATCTGATATGGAAAAAATGTTCCGTCGCATTCAGGAAAACCACACC
AGCTTGCGAGAATTGGGCAAGTATTGA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-119)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2XXQ8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.767

100

0.762

Multiple sequence alignment