Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   SCRE_RS02230 Genome accession   NC_022236
Coordinates   433991..435292 (+) Length   433 a.a.
NCBI ID   WP_020997640.1    Uniprot ID   U2ZSE5
Organism   Streptococcus constellatus subsp. pharyngis C232     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 428991..440292
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCRE_RS02205 (SCRE_0436) - 429061..430023 (-) 963 WP_020997638.1 YSIRK signal domain/LPXTG anchor domain surface protein -
  SCRE_RS09885 (SCRE_0437) - 430162..431042 (-) 881 Protein_413 ISAs1 family transposase -
  SCRE_RS09890 (SCRE_0438) - 431219..431488 (-) 270 Protein_414 IS30 family transposase -
  SCRE_RS02215 (SCRE_0439) - 431593..432317 (-) 725 Protein_415 ISL3 family transposase -
  SCRE_RS02220 (SCRE_0440) cysK 432271..433200 (-) 930 WP_020997639.1 cysteine synthase A -
  SCRE_RS02225 (SCRE_0441) - 433299..433934 (-) 636 WP_003035211.1 YigZ family protein -
  SCRE_RS02230 (SCRE_0442) comFA/cflA 433991..435292 (+) 1302 WP_020997640.1 DEAD/DEAH box helicase Machinery gene
  SCRE_RS02235 (SCRE_0443) comFC/cflB 435289..435954 (+) 666 WP_006267632.1 ComF family protein Machinery gene
  SCRE_RS02240 (SCRE_0444) hpf 436033..436575 (+) 543 WP_006267638.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  SCRE_RS02245 (SCRE_0445) rsmD 436772..437311 (+) 540 WP_020997641.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  SCRE_RS02250 (SCRE_0446) coaD 437301..437798 (+) 498 WP_006267255.1 pantetheine-phosphate adenylyltransferase -
  SCRE_RS02255 (SCRE_0447) sepM 437779..438834 (+) 1056 WP_020997642.1 SepM family pheromone-processing serine protease Regulator
  SCRE_RS02260 (SCRE_0448) - 439121..439678 (+) 558 WP_006267391.1 YutD family protein -

Sequence

Protein


Download         Length: 433 a.a.        Molecular weight: 49206.01 Da        Isoelectric Point: 8.5393

>NTDB_id=50379 SCRE_RS02230 WP_020997640.1 433991..435292(+) (comFA/cflA) [Streptococcus constellatus subsp. pharyngis C232]
MTELQDCLGRIFTKNQLSPELQLQAQTLTGMVEEKGRLSCNRCGQAIDKEKQQLPIGAYYCRSCLFLGRIRSDEHLYYFS
QEEFPKANVLKWQGKLTEFQAKVSQGLVEAVTKRKDSLVHAVTGAGKTEMIYQVVAQVINQGGAVCLASPRIDVCLELYR
RLKVDFTCDISLLHGESEAYSRSPLVIATTHHLLKFYQAFDLLIVDEVDAFPYVDNPMLYHAVHQAVKVEGTKIFLTATS
TDELDKKVAKGELTRLSLPRRFHGNPLIVPQKIWLADFQKYLGQKKLVPKLEQFVKKQRKTGFPLLIFASEIKRGQEFAE
ILQNNFPNEKVDFVASTTENRLDIVEKFRRKEITILISTTILERGVTFPCVDVFVVEANHRLFSRSALVQIAGRVGRSME
RPTGELIFFHDGTTMAIEKAIKEIREMNQEAGL

Nucleotide


Download         Length: 1302 bp        

>NTDB_id=50379 SCRE_RS02230 WP_020997640.1 433991..435292(+) (comFA/cflA) [Streptococcus constellatus subsp. pharyngis C232]
ATGACGGAATTACAAGATTGTTTAGGTCGTATTTTTACAAAAAATCAACTGTCACCAGAATTGCAATTGCAAGCACAAAC
CTTAACTGGAATGGTAGAAGAAAAAGGGAGGTTAAGCTGCAATCGCTGTGGACAAGCCATTGACAAAGAAAAACAGCAAC
TACCAATAGGTGCTTATTATTGCAGGTCTTGCTTGTTCTTAGGAAGGATCAGAAGCGATGAACATCTTTACTATTTTTCA
CAGGAAGAGTTTCCTAAAGCGAATGTCTTGAAATGGCAAGGAAAGTTGACAGAATTTCAAGCTAAGGTTTCTCAAGGACT
TGTAGAGGCGGTTACCAAACGCAAAGATAGCTTGGTTCACGCAGTCACGGGAGCCGGAAAGACGGAAATGATCTATCAGG
TGGTGGCACAAGTCATCAATCAAGGCGGAGCCGTCTGCTTAGCTAGCCCCAGAATTGATGTCTGCTTAGAACTTTATCGC
AGACTGAAAGTAGATTTTACCTGTGATATTTCACTCCTGCACGGCGAATCAGAAGCATATTCCCGCAGTCCTCTCGTGAT
TGCCACCACACATCATCTTCTCAAATTTTATCAAGCATTTGATCTTCTTATCGTTGATGAAGTAGATGCCTTTCCTTATG
TGGACAATCCGATGCTTTATCATGCAGTTCATCAGGCAGTCAAAGTAGAGGGGACGAAGATTTTCTTAACAGCAACTTCC
ACAGATGAGCTGGATAAAAAAGTGGCTAAAGGAGAATTAACTCGTTTGAGTCTACCCAGACGTTTTCATGGCAATCCTTT
GATTGTTCCGCAAAAAATTTGGTTGGCGGATTTTCAAAAATATCTTGGTCAAAAGAAGTTGGTTCCTAAGTTGGAACAAT
TTGTTAAAAAGCAAAGAAAAACAGGTTTTCCTCTTCTCATTTTTGCTTCTGAGATTAAAAGAGGACAAGAATTTGCAGAG
ATTCTCCAAAACAATTTCCCAAATGAAAAAGTTGACTTTGTAGCCTCAACGACTGAAAATCGACTCGATATTGTAGAGAA
ATTTCGTCGAAAAGAAATCACAATCTTAATATCAACGACGATTCTGGAACGTGGCGTGACTTTTCCTTGTGTAGATGTTT
TTGTGGTGGAGGCCAACCACCGTTTGTTTAGTCGCAGCGCTTTGGTACAAATTGCTGGTCGTGTTGGTCGTAGTATGGAG
CGACCAACAGGCGAGTTAATCTTTTTTCATGATGGTACAACTATGGCGATAGAAAAAGCTATTAAAGAAATTCGGGAGAT
GAATCAGGAGGCTGGTTTATGA

Domains

Predicted by InterProScan.

Helicase conserved C-terminal domain (Helicase_C)

(292-397)

DEAD/DEAH box helicase (DEAD)

(108-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2ZSE5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

70.561

98.845

0.697
  comFA/cflA Streptococcus pneumoniae D39

70.561

98.845

0.697
  comFA/cflA Streptococcus pneumoniae R6

70.561

98.845

0.697
  comFA/cflA Streptococcus pneumoniae TIGR4

70.327

98.845

0.695
  comFA/cflA Streptococcus mitis NCTC 12261

70.423

98.383

0.693
  comFA/cflA Streptococcus mitis SK321

69.953

98.383

0.688
  comFA Lactococcus lactis subsp. cremoris KW2

55.025

91.917

0.506
  comFA Latilactobacillus sakei subsp. sakei 23K

39.171

100

0.393
  comFA Bacillus subtilis subsp. subtilis str. 168

39.268

94.688

0.372

Multiple sequence alignment