Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   HWI48_RS04130 Genome accession   NZ_CP064512
Coordinates   896846..897562 (-) Length   238 a.a.
NCBI ID   WP_001829999.1    Uniprot ID   C0LF82
Organism   Staphylococcus epidermidis strain UMCG375     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 891846..902562
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI48_RS04115 (HWI48_04100) - 893127..894080 (+) 954 WP_002457062.1 LacI family DNA-binding transcriptional regulator -
  HWI48_RS04120 (HWI48_04105) - 894340..895812 (+) 1473 WP_001830011.1 sucrose-6-phosphate hydrolase -
  HWI48_RS04125 (HWI48_04110) - 895819..896778 (+) 960 WP_001830023.1 carbohydrate kinase -
  HWI48_RS04130 (HWI48_04115) agrA 896846..897562 (-) 717 WP_001829999.1 quorum-sensing response regulator AgrA Regulator
  HWI48_RS04135 (HWI48_04120) agrC 897579..898868 (-) 1290 WP_002440376.1 quorum-sensing sensor histidine kinase AgrC -
  HWI48_RS04140 (HWI48_04125) agrD 898895..899035 (-) 141 WP_001830021.1 cyclic lactone autoinducer peptide AgrD -
  HWI48_RS04145 (HWI48_04130) - 899019..899603 (-) 585 WP_001830005.1 accessory gene regulator AgrB -
  HWI48_RS04150 (HWI48_04135) hld 899921..899998 (+) 78 WP_002494082.1 delta-hemolysin -
  HWI48_RS04155 (HWI48_04140) - 900379..901164 (-) 786 WP_001830000.1 carbon-nitrogen family hydrolase -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27936.97 Da        Isoelectric Point: 5.6250

>NTDB_id=502556 HWI48_RS04130 WP_001829999.1 896846..897562(-) (agrA) [Staphylococcus epidermidis strain UMCG375]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=502556 HWI48_RS04130 WP_001829999.1 896846..897562(-) (agrA) [Staphylococcus epidermidis strain UMCG375]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCCTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAACTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAGGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTTGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGACATTATG
TTTTTTGAATCATCTACGAAATCTCATAGACTCATCGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTGATAAACAGGCATAATATTGAATCTATTG
ATTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0LF82

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

87.815

100

0.878
  comE/comE2 Streptococcus gordonii strain NCTC7865

35.178

100

0.374
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

35.178

100

0.374