Detailed information    

insolico Bioinformatically predicted

Overview

Name   agrA   Type   Regulator
Locus tag   HWI52_RS04135 Genome accession   NZ_CP064498
Coordinates   894843..895559 (-) Length   238 a.a.
NCBI ID   WP_001829999.1    Uniprot ID   C0LF82
Organism   Staphylococcus epidermidis strain UMCG379     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 889843..900559
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HWI52_RS04120 (HWI52_04110) - 891124..892077 (+) 954 WP_002457062.1 LacI family DNA-binding transcriptional regulator -
  HWI52_RS04125 (HWI52_04115) - 892337..893809 (+) 1473 WP_077755919.1 sucrose-6-phosphate hydrolase -
  HWI52_RS04130 (HWI52_04120) - 893816..894775 (+) 960 WP_002468351.1 carbohydrate kinase -
  HWI52_RS04135 (HWI52_04125) agrA 894843..895559 (-) 717 WP_001829999.1 quorum-sensing response regulator AgrA Regulator
  HWI52_RS04140 (HWI52_04130) agrC 895576..896865 (-) 1290 WP_002457064.1 quorum-sensing sensor histidine kinase AgrC -
  HWI52_RS04145 (HWI52_04135) agrD 896890..897030 (-) 141 WP_002447513.1 cyclic lactone autoinducer peptide AgrD -
  HWI52_RS04150 (HWI52_04140) - 897036..897599 (-) 564 WP_002457915.1 accessory gene regulator AgrB -
  HWI52_RS04155 (HWI52_04145) hld 897916..897993 (+) 78 WP_002494082.1 delta-hemolysin -
  HWI52_RS04160 (HWI52_04150) - 898374..899159 (-) 786 WP_002469371.1 carbon-nitrogen family hydrolase -

Sequence

Protein


Download         Length: 238 a.a.        Molecular weight: 27936.97 Da        Isoelectric Point: 5.6250

>NTDB_id=502412 HWI52_RS04135 WP_001829999.1 894843..895559(-) (agrA) [Staphylococcus epidermidis strain UMCG379]
MKIFVCEDDQRQREHMVSIIKNYIMIEEKPMELALATNDPYEVLEQSKELNDIGCYFLDIQLEADMNGIKLASEIRKHDP
VGNIIFVTSHSELTYLTFVYKVAAMDFIFKDDPSELKMRIIDCLETAHTRLKLLSKESNVDTIELKRGSNSVYVQYDDIM
FFESSTKSHRLIAHLDNRQIEFYGNLKELAQLDERFFRCHNSFVINRHNIESIDSKERIVYFKNGENCFASVRNVKKI

Nucleotide


Download         Length: 717 bp        

>NTDB_id=502412 HWI52_RS04135 WP_001829999.1 894843..895559(-) (agrA) [Staphylococcus epidermidis strain UMCG379]
ATGAAAATTTTTGTTTGTGAAGATGACCAAAGACAAAGAGAACATATGGTATCAATCATTAAAAACTACATAATGATTGA
AGAAAAGCCAATGGAGTTAGCTTTAGCAACAAATGATCCTTATGAGGTCTTAGAGCAATCAAAAGAACTTAATGACATTG
GTTGTTACTTCCTTGATATTCAATTAGAAGCTGATATGAACGGTATTAAATTAGCCAGTGAAATTCGTAAACATGATCCT
GTTGGTAATATTATATTTGTAACCAGTCACAGTGAGCTGACTTATTTGACGTTTGTTTATAAAGTGGCTGCTATGGATTT
TATTTTTAAAGATGATCCATCTGAATTAAAAATGAGAATCATAGATTGTCTCGAAACAGCACATACACGACTCAAATTAT
TATCAAAAGAAAGTAATGTAGATACGATTGAGTTAAAGCGGGGAAGTAATTCAGTATACGTTCAATATGATGATATTATG
TTTTTTGAATCATCTACGAAATCTCATAGGCTCATTGCACATCTTGATAATCGACAAATTGAATTTTATGGAAATTTAAA
GGAATTAGCACAGCTTGATGAACGTTTCTTTAGATGTCATAACAGTTTTGTGATAAACAGGCATAATATTGAATCTATTG
ACTCAAAAGAACGTATTGTTTACTTTAAGAATGGCGAAAATTGTTTCGCTTCAGTACGTAATGTTAAAAAAATATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-120)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0LF82

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  agrA Staphylococcus aureus N315

87.815

100

0.878
  comE/comE2 Streptococcus gordonii strain NCTC7865

35.178

100

0.374
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

35.178

100

0.374