Detailed information NTG0050090

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: KE3_RS09505
• Genome accession: NC_021900
• Coordinates: 1893049..1895616 (-)
• Length: 855 a.a.
• NCBI ID: WP_020917599.1
• Uniprot ID: A0AB33AP40
• Organism: Streptococcus lutetiensis 033
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1888049..1900616

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KE3_RS09485	-	1888431..1889360 (-)	930	WP_228380499.1	MFS transporter	-
KE3_RS11065	-	1889386..1889613 (-)	228	WP_228380500.1	MFS transporter	-
KE3_RS09490 (KE3_1959)	-	1889814..1890365 (-)	552	WP_043895144.1	DNA-3-methyladenine glycosylase I	-
KE3_RS09495 (KE3_1960)	ruvA	1890395..1890988 (-)	594	WP_020917597.1	Holliday junction branch migration protein RuvA	Machinery gene
KE3_RS09500 (KE3_1961)	hexB	1890989..1892929 (-)	1941	WP_020917598.1	DNA mismatch repair endonuclease MutL	Machinery gene
KE3_RS09505 (KE3_1962)	hexA	1893049..1895616 (-)	2568	WP_020917599.1	DNA mismatch repair protein MutS	Machinery gene
KE3_RS09510 (KE3_1963)	-	1895603..1895956 (-)	354	WP_020917600.1	YlbF family regulator	-
KE3_RS09515 (KE3_1964)	argR	1895953..1896390 (-)	438	WP_020917601.1	arginine repressor	-
KE3_RS09520 (KE3_1965)	argS	1896580..1898271 (+)	1692	WP_020917602.1	arginine--tRNA ligase	-
KE3_RS09525 (KE3_1966)	-	1898319..1899737 (-)	1419	WP_020917603.1	prolyl oligopeptidase family serine peptidase	-

Sequence

Protein

• Length: 855 a.a.
• Molecular weight: 95936.21 Da
• Isoelectric Point: 4.9508

>NTDB_id=50090 KE3_RS09505 WP_020917599.1 1893049..1895616(-) (hexA) [Streptococcus lutetiensis 033]
MAKDKISPGMQQYLDVKKDYPEAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLV
EMGYKVAIAEQMEDPKQAVGVVKREVIQVITPGTAVDSSKPDNANNFLVAIDSDGKTFGLAYMDVSTGEFYATSLSDFTS
LKSEILNLKAREIVVGYDLSEDEQHSLVKQLNLLLSFEQERYEDVHLIDPNLTALEISAAEKLLQYVHTTQKRELSHLQK
LVHYEIKDYLQMSYTTKSSLDLLENARTSKKHGSLYWLLDETKTAMGMRLLRNWIDRPLVNQEQIEERQNIIQVFLDNFF
ERSDLTDSLKGVYDIERLASRVSFGKANPKDLLQLGHTLGQVPTIKAILESFDSPYLDKLVNSIDTLPELKSLISSAIDS
DAQAVITEGSIIRTGFDETLDKYRKVMREGTSWIAEIEAKERAASGITNLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKA
TLKNSERFGTAELAKIEGEMLEAHEQSASLEYDIFMRVRAQVERYISRLQDLAKAISTVDVLQSLAVVAENNHYVRPTFN
NNHEIKIDKGRHAVVEKVMGTQEYIPNTITFGRNINIQLITGPNMSGKSTYMRQLALTVIMAQMGSYVAAESVSLPVFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASEKSLILFDELGRGTATYDGMALAQSIIEYIHDHIGAKTMFATHYHEL
TPLSITLTHLVNVHVATLERNGDVTFLHKIAEGPADKSYGIHVAKIAGLPEDLLQRAGSILTNLESGAAQLHLTAETEEK
TQVKTEAAEPVAEQLSLFADDSSNQEVIEALKKVDLMNLTPMQAMNVIYELKNML

Nucleotide

• Length: 2568 bp

>NTDB_id=50090 KE3_RS09505 WP_020917599.1 1893049..1895616(-) (hexA) [Streptococcus lutetiensis 033]
ATGGCAAAAGATAAAATTTCTCCAGGCATGCAACAGTATTTGGATGTCAAAAAAGACTATCCAGAGGCTTTTTTACTTTT
CCGCATGGGAGACTTTTACGAACTATTTTATGATGACGCCGTTAAGGCGGCACAGATTTTAGAGATTAGTTTAACTAGTC
GTAATAAAAATGCTGACAATCCTATTCCGATGGCTGGTGTTCCTTATCATTCAGCCCAACAATACATTGATGTCTTGGTT
GAGATGGGGTATAAGGTTGCCATTGCTGAGCAGATGGAAGATCCGAAGCAGGCAGTGGGTGTGGTTAAGCGTGAAGTCAT
TCAGGTGATTACACCAGGGACAGCGGTTGATTCTTCTAAGCCAGATAATGCTAATAATTTCTTGGTAGCCATCGATTCAG
ATGGTAAAACTTTTGGTTTGGCATACATGGATGTGTCAACGGGTGAGTTTTACGCGACAAGTTTGTCTGATTTTACAAGC
CTAAAAAGTGAGATTTTAAATCTCAAGGCTCGTGAAATCGTGGTTGGTTATGACCTTTCTGAAGATGAGCAACACAGCTT
GGTTAAACAACTCAATCTCTTATTATCGTTTGAGCAAGAGCGCTATGAAGATGTACATTTGATTGACCCTAATTTAACAG
CGTTAGAGATTTCTGCTGCTGAAAAATTACTTCAATACGTTCACACAACACAAAAACGTGAACTTAGTCACTTGCAAAAG
CTTGTTCACTATGAAATCAAAGACTATCTTCAAATGTCTTATACGACAAAATCAAGTCTTGATTTGCTAGAAAATGCCCG
TACTAGCAAGAAACACGGTAGTCTTTATTGGTTGCTTGATGAGACTAAAACTGCCATGGGGATGCGTTTGTTGCGTAACT
GGATTGATCGTCCATTGGTTAACCAAGAACAAATTGAAGAACGTCAAAATATTATTCAAGTTTTCTTAGACAACTTCTTT
GAACGTAGTGATTTGACGGACAGTCTAAAAGGTGTCTATGATATTGAACGTTTGGCTAGTCGCGTGTCATTTGGAAAAGC
CAATCCAAAAGATTTGCTTCAACTTGGTCACACTTTGGGGCAAGTGCCAACGATTAAAGCTATCTTGGAGTCTTTTGATA
GTCCGTACCTTGACAAGCTTGTCAACAGCATTGACACTTTACCAGAGCTAAAGTCATTGATTAGCTCTGCTATTGATTCA
GATGCTCAAGCGGTGATTACGGAAGGAAGTATTATCAGAACTGGTTTTGATGAGACTTTGGACAAATACCGTAAAGTCAT
GCGCGAAGGGACAAGCTGGATTGCTGAGATTGAAGCTAAAGAACGTGCGGCAAGTGGCATTACCAATCTAAAAATTGATT
ACAATAAAAAAGATGGCTATTATTTCCATGTCACAAATTCTAACCTTTCTTTGGTGCCAGATTACTTCTTCCGTAAAGCA
ACTTTGAAGAATTCAGAGCGTTTTGGTACAGCAGAATTGGCTAAAATTGAAGGTGAAATGCTAGAAGCGCATGAGCAATC
AGCGAGTCTGGAATACGATATTTTCATGCGTGTTCGCGCACAGGTGGAACGTTATATTTCACGTCTGCAAGATTTGGCAA
AAGCTATTTCTACAGTCGATGTTCTGCAAAGTTTGGCAGTGGTTGCGGAAAATAATCATTACGTGCGTCCAACTTTCAAC
AATAATCATGAAATTAAGATTGATAAAGGTCGCCATGCAGTTGTTGAAAAAGTCATGGGCACGCAAGAGTATATTCCAAA
TACCATTACATTTGGCAGAAATATCAATATTCAGCTGATTACTGGTCCAAATATGAGTGGTAAATCAACTTATATGCGTC
AGTTAGCTTTGACGGTTATCATGGCACAGATGGGGTCATACGTTGCTGCTGAGAGTGTTAGTCTTCCAGTTTTTGATGCG
ATTTTCACACGTATCGGTGCGGCGGATGATTTGATTTCAGGTCAGTCAACCTTCATGGTGGAAATGATGGAAGCCAACCA
AGCCATTAAACGTGCTAGTGAAAAATCTTTGATTCTCTTTGATGAATTGGGACGCGGGACAGCGACTTATGATGGAATGG
CTTTAGCACAATCTATCATTGAGTATATCCATGATCACATTGGTGCTAAGACCATGTTTGCGACTCACTATCATGAATTG
ACACCTCTGTCAATTACCTTGACACATCTTGTAAACGTCCATGTTGCAACGCTTGAACGTAATGGTGATGTGACTTTTCT
TCATAAAATCGCAGAAGGACCAGCTGACAAATCTTATGGTATTCACGTTGCGAAAATTGCAGGTTTGCCAGAAGATTTGT
TGCAACGAGCAGGTAGTATTTTAACCAATCTCGAATCAGGTGCTGCGCAGCTTCATTTGACAGCAGAAACTGAAGAGAAA
ACTCAAGTGAAGACAGAAGCGGCAGAACCTGTTGCAGAGCAGCTTAGCTTATTTGCAGATGACTCAAGTAACCAAGAAGT
GATTGAAGCTCTTAAAAAAGTGGACTTGATGAATCTAACACCAATGCAAGCCATGAATGTCATTTATGAATTGAAAAACA
TGTTATAA

Domains

Predicted by InterProScan.

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-505)

• MutS domain V (MutS_V) (599-785)

• MutS domain II (MutS_II) (126-239)

• MutS domain III (MutS_III) (256-546)

3D structure

• AlphaFold DB: A0AB33AP40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.813	100	0.718
mutS	Pseudomonas stutzeri strain ATCC 17587	37.113	100	0.379