Detailed information NTG0496954

Bioinformatically predicted

Overview

• Name: comD/comD1
• Type: Regulator
• Locus tag: IRE31_RS10755
• Genome accession: NZ_CP063829
• Coordinates: 2088481..2089806 (-)
• Length: 441 a.a.
• NCBI ID: WP_000362880.1
• Uniprot ID: Q79CK8
• Organism: Streptococcus pneumoniae strain 19A-ST320_99-176
• Function: phosphorylation of ComE (predicted from homology) Competence regulation

Genomic Context

Location: 2083481..2094806

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IRE31_RS10900 (IRE31_10655)	-	2085693..2086767 (-)	1075	Protein_2080	YhgE/Pip family protein	-
IRE31_RS10735 (IRE31_10660)	-	2086947..2087489 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
IRE31_RS10750 (IRE31_10675)	comE	2087732..2088484 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
IRE31_RS10755 (IRE31_10680)	comD/comD1	2088481..2089806 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
IRE31_RS10760 (IRE31_10685)	comC/comC1	2089827..2089952 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator

Sequence

Protein

• Length: 441 a.a.
• Molecular weight: 51353.78 Da
• Isoelectric Point: 6.6400

>NTDB_id=496954 IRE31_RS10755 WP_000362880.1 2088481..2089806(-) (comD/comD1) [Streptococcus pneumoniae strain 19A-ST320_99-176]
MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide

• Length: 1326 bp

>NTDB_id=496954 IRE31_RS10755 WP_000362880.1 2088481..2089806(-) (comD/comD1) [Streptococcus pneumoniae strain 19A-ST320_99-176]
ATGGATTTATTTGGATTTGGGACGGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCATTTTATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGAAAGATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

• GHKL domain (HATPase_c_5) (334-434)

3D structure

• AlphaFold DB: Q79CK8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/comD1	Streptococcus pneumoniae Rx1	100	100	1
comD/comD1	Streptococcus pneumoniae D39	100	100	1
comD/comD1	Streptococcus pneumoniae R6	100	100	1
comD/comD2	Streptococcus pneumoniae TIGR4	96.825	100	0.968
comD	Streptococcus mitis SK321	92.063	100	0.921
comD	Streptococcus mitis NCTC 12261	86.168	100	0.862
comD/comD1	Streptococcus gordonii str. Challis substr. CH1	49.733	84.807	0.422
comD/comD2	Streptococcus gordonii strain NCTC7865	49.468	85.261	0.422