Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   IRE31_RS10760 Genome accession   NZ_CP063829
Coordinates   2089827..2089952 (-) Length   41 a.a.
NCBI ID   WP_000799689.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain 19A-ST320_99-176     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2084827..2094952
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IRE31_RS10900 (IRE31_10655) - 2085693..2086767 (-) 1075 Protein_2080 YhgE/Pip family protein -
  IRE31_RS10735 (IRE31_10660) - 2086947..2087489 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  IRE31_RS10750 (IRE31_10675) comE 2087732..2088484 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  IRE31_RS10755 (IRE31_10680) comD/comD1 2088481..2089806 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  IRE31_RS10760 (IRE31_10685) comC/comC1 2089827..2089952 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4971.00 Da        Isoelectric Point: 11.0775

>NTDB_id=496955 IRE31_RS10760 WP_000799689.1 2089827..2089952(-) (comC/comC1) [Streptococcus pneumoniae strain 19A-ST320_99-176]
MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=496955 IRE31_RS10760 WP_000799689.1 2089827..2089952(-) (comC/comC1) [Streptococcus pneumoniae strain 19A-ST320_99-176]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
ATTGTCAAAATTCTTCCGTGATTTTATTTTACAAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

100

100

1
  comC/comC1 Streptococcus pneumoniae G54

100

100

1
  comC/comC1 Streptococcus pneumoniae D39

100

100

1
  comC/comC1 Streptococcus pneumoniae Rx1

100

100

1
  comC/comC2 Streptococcus pneumoniae A66

80.488

100

0.805
  comC/comC2 Streptococcus pneumoniae TIGR4

80.488

100

0.805
  comC Streptococcus mitis SK321

78.049

100

0.78
  comC Streptococcus mitis NCTC 12261

74.074

65.854

0.488
  comC/blpC Streptococcus mutans UA159

44.444

87.805

0.39