Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   KIM25_RS10835 Genome accession   NZ_CP074856
Coordinates   2187559..2188215 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain 2013C_3997_C1     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2182559..2193215
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KIM25_RS10800 (KIM25_10745) dcyD 2183438..2184424 (+) 987 WP_001128238.1 D-cysteine desulfhydrase -
  KIM25_RS10805 (KIM25_10750) tcyL 2184439..2185107 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  KIM25_RS10810 (KIM25_10755) tcyN 2185104..2185856 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  KIM25_RS10815 (KIM25_10760) sdiA 2186086..2186808 (+) 723 WP_001154265.1 transcriptional regulator SdiA -
  KIM25_RS10820 (KIM25_10765) yecF 2186876..2187100 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  KIM25_RS10825 (KIM25_10770) yecU 2187087..2187263 (-) 177 WP_001342215.1 protein YecU -
  KIM25_RS10830 - 2187301..2187417 (-) 117 WP_001302039.1 hypothetical protein -
  KIM25_RS10835 (KIM25_10775) letA 2187559..2188215 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  KIM25_RS10840 (KIM25_10780) uvrC 2188212..2190044 (+) 1833 WP_001283424.1 excinuclease ABC subunit UvrC Machinery gene
  KIM25_RS10845 (KIM25_10785) pgsA 2190101..2190649 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  KIM25_RS10865 (KIM25_10805) yecA 2191299..2191964 (+) 666 WP_000847902.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=493863 KIM25_RS10835 WP_000611328.1 2187559..2188215(+) (letA) [Escherichia coli strain 2013C_3997_C1]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=493863 KIM25_RS10835 WP_000611328.1 2187559..2188215(+) (letA) [Escherichia coli strain 2013C_3997_C1]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482