Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   INP89_RS05250 Genome accession   NZ_CP063127
Coordinates   1068532..1069206 (-) Length   224 a.a.
NCBI ID   WP_005647998.1    Uniprot ID   Q4QLV0
Organism   Haemophilus influenzae strain M1C112_1     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1063532..1074206
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  INP89_RS05230 (INP89_05225) hinT 1065230..1065580 (+) 351 WP_005627389.1 purine nucleoside phosphoramidase -
  INP89_RS05235 (INP89_05230) - 1065580..1065930 (+) 351 WP_005647993.1 YcfL family protein -
  INP89_RS05240 (INP89_05235) nagZ 1065934..1066986 (+) 1053 WP_074039345.1 beta-N-acetylhexosaminidase -
  INP89_RS05245 (INP89_05240) rlmC 1066983..1068167 (+) 1185 WP_197541577.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
  INP89_RS05250 (INP89_05245) crp 1068532..1069206 (-) 675 WP_005647998.1 cAMP-activated global transcriptional regulator CRP Regulator
  INP89_RS05255 (INP89_05250) - 1069191..1069442 (-) 252 WP_005647999.1 YheU family protein -
  INP89_RS05260 (INP89_05255) slmA 1069464..1070120 (-) 657 WP_005648000.1 nucleoid occlusion factor SlmA -
  INP89_RS05265 (INP89_05260) dut 1070124..1070579 (-) 456 WP_005631431.1 dUTP diphosphatase -
  INP89_RS05270 (INP89_05265) coaBC 1070627..1071829 (-) 1203 WP_012055320.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
  INP89_RS05275 (INP89_05270) radC 1071992..1072657 (+) 666 WP_074039347.1 RadC family protein -
  INP89_RS05280 (INP89_05275) rpmB 1072871..1073107 (+) 237 WP_005542826.1 50S ribosomal protein L28 -
  INP89_RS05285 (INP89_05280) rpmG 1073119..1073289 (+) 171 WP_005613503.1 50S ribosomal protein L33 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25151.85 Da        Isoelectric Point: 6.8375

>NTDB_id=493223 INP89_RS05250 WP_005647998.1 1068532..1069206(-) (crp) [Haemophilus influenzae strain M1C112_1]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide


Download         Length: 675 bp        

>NTDB_id=493223 INP89_RS05250 WP_005647998.1 1068532..1069206(-) (crp) [Haemophilus influenzae strain M1C112_1]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAGTATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGT
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTCACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTAGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(36-124)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(156-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QLV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Haemophilus influenzae Rd KW20

100

100

1
  crp Vibrio cholerae strain A1552

75.49

91.071

0.687
  crp Acinetobacter baumannii D1279779

48.705

86.161

0.42