Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   ILP78_RS05130 Genome accession   NZ_CP062465
Coordinates   1030579..1031208 (+) Length   209 a.a.
NCBI ID   WP_000153532.1    Uniprot ID   A0A481NSL0
Organism   Staphylococcus aureus strain MRSA - AMRF 6     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1025579..1036208
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ILP78_RS05105 (ILP78_05105) - 1026014..1027000 (-) 987 WP_000999713.1 FUSC family protein -
  ILP78_RS05110 (ILP78_05110) map 1027472..1028230 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  ILP78_RS05115 (ILP78_05115) - 1028447..1028833 (+) 387 WP_001110179.1 hypothetical protein -
  ILP78_RS05120 (ILP78_05120) liaF 1028848..1029549 (+) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  ILP78_RS05125 (ILP78_05125) vraS 1029546..1030589 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  ILP78_RS05130 (ILP78_05130) vraR 1030579..1031208 (+) 630 WP_000153532.1 two-component system response regulator VraR Regulator
  ILP78_RS05135 (ILP78_05135) - 1031320..1032537 (-) 1218 WP_000037078.1 YihY/virulence factor BrkB family protein -
  ILP78_RS05140 (ILP78_05140) - 1032815..1033090 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  ILP78_RS05145 (ILP78_05145) - 1033097..1033561 (-) 465 WP_000567539.1 low molecular weight protein-tyrosine-phosphatase -
  ILP78_RS05150 (ILP78_05150) - 1033708..1033908 (+) 201 WP_000180460.1 DUF1128 family protein -
  ILP78_RS05155 (ILP78_05155) - 1033911..1035167 (+) 1257 WP_072398252.1 aminopeptidase -
  ILP78_RS05160 (ILP78_05160) - 1035257..1035787 (+) 531 WP_000184383.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23516.29 Da        Isoelectric Point: 5.1703

>NTDB_id=490191 ILP78_RS05130 WP_000153532.1 1030579..1031208(+) (vraR) [Staphylococcus aureus strain MRSA - AMRF 6]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSIGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=490191 ILP78_RS05130 WP_000153532.1 1030579..1031208(+) (vraR) [Staphylococcus aureus strain MRSA - AMRF 6]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAGGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTATAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTCATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Bacterial regulatory proteins, luxR family (GerE)

(147-202)

Response regulator receiver domain (Response_reg)

(5-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A481NSL0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373