Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Machinery gene
Locus tag   NMBH4476_RS14975 Genome accession   NC_017516
Coordinates   2100164..2100628 (-) Length   154 a.a.
NCBI ID   WP_162467384.1    Uniprot ID   -
Organism   Neisseria meningitidis H44/76     
Function   DNA binding (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 2089576..2100463 2100164..2100628 flank -299


Gene organization within MGE regions


Location: 2089576..2100628
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMBH4476_RS10775 (NMBH4476_1945) - 2089576..2091219 (+) 1644 WP_002223143.1 DUF4435 domain-containing protein -
  NMBH4476_RS10780 (NMBH4476_1946) - 2091263..2091445 (+) 183 WP_002223144.1 hypothetical protein -
  NMBH4476_RS10785 (NMBH4476_1947) lpt3 2091657..2093234 (+) 1578 WP_002223145.1 lipooligosaccharide phosphoethanolamine transferase -
  NMBH4476_RS15755 - 2093336..2094562 (+) 1227 Protein_2014 DUF3418 domain-containing protein -
  NMBH4476_RS10790 (NMBH4476_1948) - 2094935..2096719 (+) 1785 Protein_2015 DUF3418 domain-containing protein -
  NMBH4476_RS10795 (NMBH4476_1949) - 2096752..2097843 (-) 1092 WP_002225876.1 XRE family transcriptional regulator -
  NMBH4476_RS10800 (NMBH4476_1950) - 2097859..2098503 (-) 645 WP_002223148.1 hypothetical protein -
  NMBH4476_RS15230 (NMBH4476_1952) - 2098860..2099012 (+) 153 WP_002223150.1 hypothetical protein -
  NMBH4476_RS15940 (NMBH4476_1953) - 2099269..2099537 (+) 269 Protein_2019 5'-nucleotidase -
  NMBH4476_RS10820 (NMBH4476_1954) comP 2099627..2100076 (-) 450 WP_002214937.1 type IV pilin protein Machinery gene
  NMBH4476_RS14975 comE 2100164..2100628 (-) 465 WP_162467384.1 ComEA family DNA-binding protein Machinery gene

Sequence

Protein


Download         Length: 154 a.a.        Molecular weight: 16501.79 Da        Isoelectric Point: 10.9585

>NTDB_id=48079 NMBH4476_RS14975 WP_162467384.1 2100164..2100628(-) (comE) [Neisseria meningitidis H44/76]
MLCPEKMSVMAGRHPYGVRSGLRRNGLKLWDIHFRMTRFIVARCGLLFATLKGKTMKKMFVLFCMLFSCAFSLAAVNINA
ASQQELEALPGIGPAKAKAIAEYRAQNGAFKSVDDLTKVKGIGPAVLAKLKDQASVGAPAPKGPAKPAIPAAKK

Nucleotide


Download         Length: 465 bp        

>NTDB_id=48079 NMBH4476_RS14975 WP_162467384.1 2100164..2100628(-) (comE) [Neisseria meningitidis H44/76]
TTGCTTTGCCCGGAAAAAATGTCGGTGATGGCGGGACGGCATCCGTACGGTGTCCGGTCGGGTTTGCGGAGGAACGGCTT
GAAACTTTGGGATATTCATTTTAGAATGACTCGTTTTATCGTCGCAAGATGCGGTTTATTGTTTGCAACCCTTAAAGGAA
AAACCATGAAGAAAATGTTCGTGCTGTTCTGTATGCTGTTCTCCTGCGCCTTCTCCCTTGCGGCGGTAAACATCAATGCG
GCTTCGCAGCAGGAGTTGGAGGCGCTGCCGGGCATAGGCCCGGCGAAGGCGAAGGCCATTGCGGAATACCGTGCGCAAAA
CGGTGCGTTCAAGTCTGTAGACGATTTGACCAAGGTAAAGGGCATCGGCCCTGCGGTGCTGGCGAAGCTGAAGGACCAGG
CTTCGGTCGGCGCGCCCGCACCAAAAGGCCCAGCCAAACCGGCTATACCGGCCGCTAAAAAATAG

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(75-133)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734
  comE Neisseria gonorrhoeae MS11

92.623

79.221

0.734

Multiple sequence alignment