Detailed information NTG0047717

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LLH_RS11975
• Genome accession: NC_017492
• Coordinates: 2307714..2308745 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris subsp. cremoris A76
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2302714..2313745

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLH_RS11945 (llh_12495)	-	2303083..2304194 (+)	1112	WP_155114649.1	IS3-like element IS981 family transposase	-
LLH_RS11950 (llh_12500)	-	2304205..2304414 (-)	210	WP_014573363.1	hypothetical protein	-
LLH_RS11955 (llh_12505)	-	2304401..2304610 (-)	210	WP_011677212.1	hypothetical protein	-
LLH_RS11965 (llh_12515)	-	2304898..2305788 (+)	891	WP_014573365.1	IS982-like element IS982B family transposase	-
LLH_RS11970 (llh_12520)	kwcM	2305895..2307214 (-)	1320	WP_014573366.1	KxxxW cyclic peptide radical SAM maturase	-
LLH_RS13725 (llh_12525)	-	2307282..2307395 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
LLH_RS11975 (llh_12530)	sepM	2307714..2308745 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
LLH_RS11980 (llh_12535)	coaD	2308729..2309229 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
LLH_RS11985 (llh_12540)	rsmD	2309277..2309816 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LLH_RS11990 (llh_12545)	-	2309987..2311207 (-)	1221	WP_011677216.1	MFS transporter	-
LLH_RS11995 (llh_12550)	lmrP	2311291..2312517 (-)	1227	Protein_2315	multidrug efflux MFS transporter LmrP	-
LLH_RS12000 (llh_12560)	-	2312705..2313199 (+)	495	WP_021211251.1	RNA polymerase sigma factor	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=47717 LLH_RS11975 WP_011677213.1 2307714..2308745(-) (sepM) [Lactococcus cremoris subsp. cremoris A76]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=47717 LLH_RS11975 WP_011677213.1 2307714..2308745(-) (sepM) [Lactococcus cremoris subsp. cremoris A76]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49