Detailed information NTG0474830

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: H7X60_RS04745
• Genome accession: NZ_CP060266
• Coordinates: 953630..954940 (-)
• Length: 436 a.a.
• NCBI ID: WP_010922354.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain SP1450
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 948630..959940

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7X60_RS04720 (H7X60_04705)	-	949234..950286 (-)	1053	WP_002989701.1	BMP family lipoprotein	-
H7X60_RS04725 (H7X60_04710)	-	950380..950769 (-)	390	WP_011285547.1	cytidine deaminase	-
H7X60_RS04730 (H7X60_04715)	-	951428..952015 (-)	588	WP_011285548.1	class I SAM-dependent methyltransferase	-
H7X60_RS04735 (H7X60_04720)	coaA	952283..953203 (+)	921	WP_010922353.1	type I pantothenate kinase	-
H7X60_RS04740 (H7X60_04725)	rpsT	953257..953505 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
H7X60_RS04745 (H7X60_04730)	ciaH	953630..954940 (-)	1311	WP_010922354.1	sensor histidine kinase	Regulator
H7X60_RS04750 (H7X60_04735)	ciaR	954933..955607 (-)	675	WP_010922355.1	response regulator transcription factor	Regulator
H7X60_RS04755 (H7X60_04740)	-	955953..958490 (-)	2538	WP_010922356.1	M1 family metallopeptidase	-
H7X60_RS04760 (H7X60_04745)	phoU	958695..959348 (-)	654	WP_027969197.1	phosphate signaling complex protein PhoU	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50013.52 Da
• Isoelectric Point: 9.0831

>NTDB_id=474830 H7X60_RS04745 WP_010922354.1 953630..954940(-) (ciaH) [Streptococcus pyogenes strain SP1450]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKRRLGSIETTSLMNFYGQEEKYHTITVGVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=474830 H7X60_RS04745 WP_010922354.1 953630..954940(-) (ciaH) [Streptococcus pyogenes strain SP1450]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACGCCGGTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACTGTAGGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTATGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAATTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAATGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516