Detailed information NTG0474231

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: H6Y62_RS05030
• Genome accession: NZ_CP060160
• Coordinates: 1078198..1079241 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain MBAZ2
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1073198..1084241

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H6Y62_RS05005 (H6Y62_05005)	-	1073488..1074849 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
H6Y62_RS05010 (H6Y62_05010)	-	1074983..1075963 (-)	981	WP_002492696.1	FUSC family protein	-
H6Y62_RS05015 (H6Y62_05015)	map	1076208..1076963 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
H6Y62_RS05020 (H6Y62_05020)	-	1077089..1077475 (+)	387	WP_002477960.1	hypothetical protein	-
H6Y62_RS05025 (H6Y62_05025)	liaF	1077500..1078201 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
H6Y62_RS05030 (H6Y62_05030)	vraS	1078198..1079241 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
H6Y62_RS05035 (H6Y62_05035)	vraR	1079231..1079860 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
H6Y62_RS05040 (H6Y62_05040)	-	1080033..1081262 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
H6Y62_RS05045 (H6Y62_05045)	-	1081465..1081749 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
H6Y62_RS05050 (H6Y62_05050)	-	1081756..1082220 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
H6Y62_RS05055 (H6Y62_05055)	-	1082384..1082569 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
H6Y62_RS05060 (H6Y62_05060)	-	1082582..1083820 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=474231 H6Y62_RS05030 WP_002461334.1 1078198..1079241(+) (vraS) [Staphylococcus lugdunensis strain MBAZ2]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=474231 H6Y62_RS05030 WP_002461334.1 1078198..1079241(+) (vraS) [Staphylococcus lugdunensis strain MBAZ2]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911