Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   JTC67_RS18975 Genome accession   NZ_CP070229
Coordinates   3736741..3737400 (-) Length   219 a.a.
NCBI ID   WP_233679705.1    Uniprot ID   -
Organism   Escherichia coli strain EC12     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3731741..3742400
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JTC67_RS18950 (JTC67_18780) - 3732483..3733430 (+) 948 WP_001296418.1 iron-siderophore ABC transporter substrate-binding protein -
  JTC67_RS18955 (JTC67_18785) - 3733427..3734314 (+) 888 WP_000614943.1 MurR/RpiR family transcriptional regulator -
  JTC67_RS18960 (JTC67_18790) ygiN 3734359..3734673 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  JTC67_RS18965 (JTC67_18795) mdaB 3734704..3735285 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  JTC67_RS18970 (JTC67_18800) qseC 3735395..3736744 (-) 1350 WP_001539721.1 quorum sensing histidine kinase QseC -
  JTC67_RS18975 (JTC67_18805) ciaR 3736741..3737400 (-) 660 WP_233679705.1 quorum sensing response regulator transcription factor QseB Regulator
  JTC67_RS18980 (JTC67_18810) ygiW 3737552..3737944 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  JTC67_RS18985 (JTC67_18815) ygiV 3737997..3738479 (+) 483 WP_000183491.1 AraC family transcriptional regulator -
  JTC67_RS18990 (JTC67_18820) ygiS 3738588..3740195 (+) 1608 WP_001296417.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24634.58 Da        Isoelectric Point: 6.6491

>NTDB_id=473667 JTC67_RS18975 WP_233679705.1 3736741..3737400(-) (ciaR) [Escherichia coli strain EC12]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELCHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=473667 JTC67_RS18975 WP_233679705.1 3736741..3737400(-) (ciaR) [Escherichia coli strain EC12]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCTGTATTGATCCTGACTGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGTGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365