Detailed information    

insolico Bioinformatically predicted

Overview

Name   crp   Type   Regulator
Locus tag   R2846_RS06870 Genome accession   NC_017452
Coordinates   1429195..1429869 (-) Length   224 a.a.
NCBI ID   WP_005647998.1    Uniprot ID   Q4QLV0
Organism   Haemophilus influenzae R2846     
Function   promote expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1424195..1434869
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R2846_RS06850 (R2846_1348) hinT 1425904..1426254 (+) 351 WP_005627389.1 purine nucleoside phosphoramidase -
  R2846_RS06855 (R2846_1349) - 1426254..1426604 (+) 351 WP_014550994.1 YcfL family protein -
  R2846_RS06860 (R2846_1350) nagZ 1426608..1427662 (+) 1055 Protein_1324 beta-N-acetylhexosaminidase -
  R2846_RS06865 (R2846_1351) rlmC 1427655..1428830 (+) 1176 WP_014550995.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
  R2846_RS06870 (R2846_1352) crp 1429195..1429869 (-) 675 WP_005647998.1 cAMP-activated global transcriptional regulator CRP Regulator
  R2846_RS06875 (R2846_1353) - 1429854..1430105 (-) 252 WP_005647999.1 YheU family protein -
  R2846_RS06880 (R2846_1354) slmA 1430127..1430786 (-) 660 WP_014550996.1 nucleoid occlusion factor SlmA -
  R2846_RS06885 (R2846_1355) dut 1430790..1431245 (-) 456 WP_014550997.1 dUTP diphosphatase -
  R2846_RS06890 (R2846_1356) coaBC 1431293..1432495 (-) 1203 WP_014550998.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
  R2846_RS06895 (R2846_1357) radC 1432658..1433323 (+) 666 WP_013527272.1 RadC family protein -
  R2846_RS06900 (R2846_1358) rpmB 1433537..1433773 (+) 237 WP_005542826.1 50S ribosomal protein L28 -
  R2846_RS06905 (R2846_1359) rpmG 1433785..1433955 (+) 171 WP_005613503.1 50S ribosomal protein L33 -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25151.85 Da        Isoelectric Point: 6.8375

>NTDB_id=47305 R2846_RS06870 WP_005647998.1 1429195..1429869(-) (crp) [Haemophilus influenzae R2846]
MSNELTEIDEVVTSSQEEATQRDPVLDWFLTHCHLHKYPAKSTLIHAGEDATTLYYVIKGSVMVSSKDDEGKEMILTYLG
AGQFFGEAGLFDEGSKRSAWVKTKTTCEIAEISYKKYRQLIQANPEILMFLTAQLARRLQNTSRQVTNLAFLDVAGRIAQ
TLMNLAKQPEAMTHPDGMQIKITRQEIGQMVGCSRETVGRIIKMLEDQNLIHAHGKTIVVYGAR

Nucleotide


Download         Length: 675 bp        

>NTDB_id=47305 R2846_RS06870 WP_005647998.1 1429195..1429869(-) (crp) [Haemophilus influenzae R2846]
ATGTCAAATGAATTAACCGAAATTGATGAAGTTGTAACCTCCTCTCAAGAAGAAGCAACTCAACGAGATCCCGTTTTAGA
TTGGTTTCTTACTCACTGCCATTTGCATAAATATCCTGCAAAATCAACTTTAATTCATGCTGGGGAAGATGCGACCACGC
TGTATTATGTAATTAAAGGTTCTGTAATGGTATCTTCAAAAGATGATGAAGGCAAAGAGATGATCCTCACTTACTTAGGT
GCAGGACAATTTTTTGGCGAAGCGGGATTATTTGATGAAGGTTCAAAACGATCAGCTTGGGTAAAAACAAAAACAACATG
TGAAATTGCTGAAATTTCCTATAAGAAATATCGCCAGTTGATTCAGGCAAACCCTGAAATCTTAATGTTTCTTACTGCAC
AATTGGCAAGACGTTTGCAAAATACATCACGTCAAGTCACGAATTTGGCATTTTTAGACGTCGCAGGTCGCATCGCTCAA
ACTTTAATGAACTTAGCTAAACAGCCTGAAGCAATGACGCATCCTGATGGTATGCAAATCAAAATTACACGCCAAGAAAT
AGGGCAAATGGTGGGTTGTTCACGAGAAACTGTGGGGCGCATTATTAAGATGTTGGAGGATCAGAATCTTATCCACGCTC
ATGGAAAAACAATCGTTGTATATGGCGCAAGATAA

Domains

Predicted by InterproScan.

Cyclic nucleotide-binding domain (cNMP_binding)

(36-124)

Crp-like helix-turn-helix domain (HTH_Crp_2)

(156-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q4QLV0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  crp Haemophilus influenzae Rd KW20

100

100

1
  crp Vibrio cholerae strain A1552

75.49

91.071

0.687
  crp Acinetobacter baumannii D1279779

48.705

86.161

0.42

Multiple sequence alignment