Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6K18_RS12215 Genome accession   NZ_CP070007
Coordinates   2538995..2539654 (-) Length   219 a.a.
NCBI ID   WP_001221510.1    Uniprot ID   -
Organism   Escherichia coli strain FDAARGOS_1288     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2533995..2544654
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6K18_RS12190 (I6K18_12190) parE 2534086..2535978 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  I6K18_RS12195 (I6K18_12195) ygiN 2536026..2536340 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  I6K18_RS12200 (I6K18_12200) mdaB 2536371..2536952 (-) 582 WP_000072421.1 NADPH:quinone oxidoreductase MdaB -
  I6K18_RS12205 (I6K18_12205) ygiZ 2537271..2537603 (+) 333 WP_000917684.1 DUF2645 family protein -
  I6K18_RS12210 (I6K18_12210) qseC 2537649..2538998 (-) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  I6K18_RS12215 (I6K18_12215) ciaR 2538995..2539654 (-) 660 WP_001221510.1 quorum sensing response regulator transcription factor QseB Regulator
  I6K18_RS12220 (I6K18_12220) ygiW 2539806..2540198 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  I6K18_RS12225 (I6K18_12225) ygiV 2540251..2540733 (+) 483 WP_000183505.1 GyrI-like domain-containing protein -
  I6K18_RS12230 (I6K18_12230) mqsR 2540938..2541234 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  I6K18_RS12235 (I6K18_12235) mqsA 2541236..2541631 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  I6K18_RS12240 (I6K18_12240) ygiS 2541764..2543371 (+) 1608 WP_001735743.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24686.69 Da        Isoelectric Point: 8.0731

>NTDB_id=471875 I6K18_RS12215 WP_001221510.1 2538995..2539654(-) (ciaR) [Escherichia coli strain FDAARGOS_1288]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILRKWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=471875 I6K18_RS12215 WP_001221510.1 2538995..2539654(-) (ciaR) [Escherichia coli strain FDAARGOS_1288]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCAAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

37.885

100

0.393
  ciaR Streptococcus pneumoniae D39

37.885

100

0.393
  ciaR Streptococcus pneumoniae R6

37.885

100

0.393
  ciaR Streptococcus pneumoniae TIGR4

37.885

100

0.393
  ciaR Streptococcus mutans UA159

35.426

100

0.361