Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   JSQ74_RS10870 Genome accession   NZ_CP069710
Coordinates   2262251..2262910 (+) Length   219 a.a.
NCBI ID   WP_001221503.1    Uniprot ID   -
Organism   Escherichia coli strain EA2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2257251..2267910
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JSQ74_RS10845 (JSQ74_10845) ygiS 2258534..2260141 (-) 1608 WP_204084400.1 ABC transporter substrate-binding protein -
  JSQ74_RS10850 (JSQ74_10850) mqsA 2260274..2260669 (-) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  JSQ74_RS10855 (JSQ74_10855) mqsR 2260671..2260967 (-) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  JSQ74_RS10860 (JSQ74_10860) ygiV 2261172..2261654 (-) 483 WP_000183494.1 GyrI-like domain-containing protein -
  JSQ74_RS10865 (JSQ74_10865) ygiW 2261707..2262099 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  JSQ74_RS10870 (JSQ74_10870) ciaR 2262251..2262910 (+) 660 WP_001221503.1 quorum sensing response regulator transcription factor QseB Regulator
  JSQ74_RS10875 (JSQ74_10875) qseC 2262907..2264256 (+) 1350 WP_151317648.1 quorum sensing histidine kinase QseC -
  JSQ74_RS10880 (JSQ74_10880) ygiZ 2264302..2264634 (-) 333 WP_000914690.1 DUF2645 family protein -
  JSQ74_RS23735 - 2264641..2265351 (-) 711 WP_000834029.1 hypothetical protein -
  JSQ74_RS23740 - 2265354..2265833 (-) 480 WP_251302148.1 Hcp family type VI secretion system effector -
  JSQ74_RS10890 (JSQ74_10890) mdaB 2266083..2266664 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  JSQ74_RS10895 (JSQ74_10895) ygiN 2266695..2267009 (+) 315 WP_000958598.1 putative quinol monooxygenase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24711.65 Da        Isoelectric Point: 6.6543

>NTDB_id=470016 JSQ74_RS10870 WP_001221503.1 2262251..2262910(+) (ciaR) [Escherichia coli strain EA2]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKELALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=470016 JSQ74_RS10870 WP_001221503.1 2262251..2262910(+) (ciaR) [Escherichia coli strain EA2]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAACTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAATTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

37.885

100

0.393
  ciaR Streptococcus pneumoniae D39

37.885

100

0.393
  ciaR Streptococcus pneumoniae R6

37.885

100

0.393
  ciaR Streptococcus pneumoniae TIGR4

37.885

100

0.393
  ciaR Streptococcus mutans UA159

35.426

100

0.361