Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   H1R75_RS05785 Genome accession   NZ_CP059471
Coordinates   1123138..1124367 (-) Length   409 a.a.
NCBI ID   WP_182001168.1    Uniprot ID   -
Organism   Streptococcus equinus strain MDC1     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1124591..1165139 1123138..1124367 flank 224


Gene organization within MGE regions


Location: 1123138..1165139
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1R75_RS05785 (H1R75_05785) clpX 1123138..1124367 (-) 1230 WP_182001168.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  H1R75_RS05790 (H1R75_05790) - 1124591..1125085 (-) 495 WP_074628605.1 dihydrofolate reductase -
  H1R75_RS05795 (H1R75_05795) - 1125169..1126008 (-) 840 WP_021142433.1 thymidylate synthase -
  H1R75_RS05800 (H1R75_05800) - 1126341..1127519 (+) 1179 WP_074483567.1 hydroxymethylglutaryl-CoA synthase -
  H1R75_RS05805 (H1R75_05805) - 1127506..1128780 (+) 1275 WP_182001169.1 hydroxymethylglutaryl-CoA reductase, degradative -
  H1R75_RS05810 (H1R75_05810) - 1129014..1129457 (+) 444 WP_094140494.1 DUF1836 domain-containing protein -
  H1R75_RS05815 (H1R75_05815) trhA 1129447..1130103 (+) 657 WP_024343981.1 PAQR family membrane homeostasis protein TrhA -
  H1R75_RS05820 (H1R75_05820) fni 1130128..1131126 (-) 999 WP_182001170.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  H1R75_RS05825 (H1R75_05825) - 1131123..1132120 (-) 998 Protein_1086 phosphomevalonate kinase -
  H1R75_RS05830 (H1R75_05830) mvaD 1132107..1133057 (-) 951 WP_021142444.1 diphosphomevalonate decarboxylase -
  H1R75_RS05835 (H1R75_05835) mvk 1133039..1133917 (-) 879 WP_024343978.1 mevalonate kinase -
  H1R75_RS05840 (H1R75_05840) - 1134083..1134841 (-) 759 WP_020916913.1 amino acid ABC transporter ATP-binding protein -
  H1R75_RS05845 (H1R75_05845) - 1134862..1135542 (-) 681 WP_182001171.1 amino acid ABC transporter permease -
  H1R75_RS05850 (H1R75_05850) - 1135553..1136245 (-) 693 WP_074628597.1 amino acid ABC transporter permease -
  H1R75_RS05855 (H1R75_05855) - 1136255..1137133 (-) 879 WP_182001172.1 transporter substrate-binding domain-containing protein -
  H1R75_RS05860 (H1R75_05860) - 1137185..1138216 (-) 1032 WP_413251976.1 uroporphyrinogen decarboxylase family protein -
  H1R75_RS05865 (H1R75_05865) - 1138802..1139716 (+) 915 WP_182001173.1 LysR family transcriptional regulator -
  H1R75_RS05870 (H1R75_05870) - 1139778..1140623 (+) 846 WP_182001174.1 aldo/keto reductase -
  H1R75_RS05875 (H1R75_05875) - 1140659..1141882 (-) 1224 WP_024343970.1 ATP-binding protein -
  H1R75_RS05880 (H1R75_05880) - 1141890..1142570 (-) 681 WP_024343969.1 response regulator transcription factor -
  H1R75_RS05885 (H1R75_05885) - 1142586..1143203 (-) 618 WP_182001175.1 GTP pyrophosphokinase family protein -
  H1R75_RS05890 (H1R75_05890) - 1143293..1143487 (-) 195 Protein_1099 ABC transporter permease -
  H1R75_RS05895 (H1R75_05895) - 1143487..1143927 (-) 441 WP_182001176.1 MarR family winged helix-turn-helix transcriptional regulator -
  H1R75_RS05900 (H1R75_05900) - 1143930..1145795 (-) 1866 WP_182001177.1 hypothetical protein -
  H1R75_RS05905 (H1R75_05905) rcrQ 1145903..1147675 (-) 1773 WP_182001178.1 ABC transporter ATP-binding protein Regulator
  H1R75_RS05910 (H1R75_05910) rcrP 1147665..1149479 (-) 1815 WP_182001179.1 ABC transporter ATP-binding protein Regulator
  H1R75_RS05915 (H1R75_05915) rcrR 1149483..1149923 (-) 441 WP_004232103.1 MarR family winged helix-turn-helix transcriptional regulator Regulator
  H1R75_RS05920 (H1R75_05920) - 1150071..1150481 (-) 411 WP_074628585.1 peptide deformylase -
  H1R75_RS05925 (H1R75_05925) - 1150484..1150987 (-) 504 WP_182001180.1 GNAT family N-acetyltransferase -
  H1R75_RS05930 (H1R75_05930) gdhA 1151140..1152489 (-) 1350 WP_021142476.1 NADP-specific glutamate dehydrogenase -
  H1R75_RS05935 (H1R75_05935) - 1152719..1153216 (+) 498 WP_027968633.1 DUF308 domain-containing protein -
  H1R75_RS05940 (H1R75_05940) queF 1153255..1153746 (-) 492 WP_021142478.1 preQ(1) synthase -
  H1R75_RS05945 (H1R75_05945) queE 1153761..1154474 (-) 714 WP_039690525.1 7-carboxy-7-deazaguanine synthase QueE -
  H1R75_RS05950 (H1R75_05950) queD 1154467..1154913 (-) 447 WP_027968631.1 6-carboxytetrahydropterin synthase QueD -
  H1R75_RS05955 (H1R75_05955) queC 1154913..1155566 (-) 654 WP_004232125.1 7-cyano-7-deazaguanine synthase QueC -
  H1R75_RS05960 (H1R75_05960) - 1155732..1157501 (-) 1770 WP_182001181.1 ABC transporter ATP-binding protein -
  H1R75_RS05965 (H1R75_05965) - 1157504..1159243 (-) 1740 WP_074479620.1 ABC transporter ATP-binding protein -
  H1R75_RS05970 (H1R75_05970) - 1159288..1161156 (-) 1869 WP_182001182.1 ABC-F family ATP-binding cassette domain-containing protein -
  H1R75_RS05975 (H1R75_05975) - 1161153..1162358 (-) 1206 WP_024343955.1 CCA tRNA nucleotidyltransferase -
  H1R75_RS05980 (H1R75_05980) dapB 1162355..1163122 (-) 768 WP_004232139.1 4-hydroxy-tetrahydrodipicolinate reductase -
  H1R75_RS05985 (H1R75_05985) - 1163142..1163990 (-) 849 WP_027968628.1 DegV family protein -
  H1R75_RS05990 (H1R75_05990) - 1163990..1164370 (-) 381 WP_021142489.1 DUF1149 family protein -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 45186.61 Da        Isoelectric Point: 4.4289

>NTDB_id=469829 H1R75_RS05785 WP_182001168.1 1123138..1124367(-) (clpX) [Streptococcus equinus strain MDC1]
MVGNRTNDVKVYCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLAEVPKPKELLATLDEYVVGQER
AKRALAVAVYNHYKRVSFAESRDEEDVELQKSNILLIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADFNIERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEDIVKQRLGEKIIGFGQNNRKIDEDASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLTADDLVRI
LTEPRNALVKQYQTLLSYDGVDLEFDEDALQAIANKAIERKTGARGLRSIIEETMMDIMFEIPSREEVTKVRITKDAVEG
TDKPILETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=469829 H1R75_RS05785 WP_182001168.1 1123138..1124367(-) (clpX) [Streptococcus equinus strain MDC1]
ATGGTTGGAAATCGAACAAATGATGTAAAAGTTTATTGCTCATTTTGTGGAAAAAGCCAAGACGAAGTAAAAAAAATTAT
TGCAGGAAATAATGTTTTTATTTGTAATGAATGTGTGGCTTTATCCCAAGAGATTATTAAAGAAGAATTAGCAGAAGAAG
TTCTTGCAGATTTGGCAGAAGTTCCAAAACCAAAAGAATTACTAGCTACCCTTGATGAATATGTTGTTGGTCAAGAACGT
GCAAAACGCGCCCTTGCAGTAGCAGTTTACAATCACTACAAGCGTGTATCTTTTGCTGAGAGTCGTGATGAAGAAGATGT
TGAATTGCAAAAATCAAACATCTTGCTTATCGGACCAACAGGGTCAGGGAAAACTTTCCTTGCTCAAACATTGGCTAAAA
GTCTTAATGTTCCATTTGCAATTGCAGATGCGACATCATTGACTGAAGCAGGATATGTCGGTGAAGATGTTGAAAATATC
CTTTTGAAACTGATTCAAGCAGCTGATTTTAATATTGAACGTGCTGAACGTGGTATTATCTACGTTGACGAAATTGATAA
AATCGCTAAAAAAGGTGAAAATGTTTCAATTACTCGTGACGTTTCAGGTGAAGGTGTTCAACAAGCTCTCCTTAAAATCA
TTGAAGGAACAGTTGCTAGCGTACCACCACAAGGTGGACGTAAACACCCTAACCAAGAAATGATTCAAATTGATACCAAG
AACATTCTTTTCATCGTTGGTGGTGCGTTTGATGGTATCGAAGATATTGTTAAACAACGTCTTGGTGAAAAAATTATTGG
TTTTGGTCAAAATAACCGTAAAATTGATGAAGATGCATCTTATATGCAAGAAATCATCTCAGAAGATATTCAAAAATTTG
GTCTTATTCCAGAGTTTATCGGACGCTTGCCTGTAGTGGCTGCGCTTGAACAATTGACTGCGGATGATTTGGTTCGTATC
TTGACTGAACCTCGCAATGCCTTGGTTAAACAATACCAAACATTGCTATCTTATGATGGTGTTGATTTGGAATTTGATGA
AGATGCTCTTCAAGCAATTGCCAATAAAGCTATCGAACGTAAGACAGGTGCGCGTGGACTTCGTTCAATTATTGAAGAAA
CAATGATGGATATCATGTTTGAAATTCCTAGTCGCGAAGAAGTTACCAAAGTTCGCATCACTAAAGATGCTGTCGAAGGT
ACTGATAAACCTATCTTAGAAACTGCATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-390)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

89.976

100

0.9
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.853

98.044

0.577