Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   H1A19_RS06520 Genome accession   NZ_CP059383
Coordinates   1247271..1248584 (+) Length   437 a.a.
NCBI ID   WP_000042580.1    Uniprot ID   A0AAW3HV66
Organism   Streptococcus agalactiae strain BJ01     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1249355..1315723 1247271..1248584 flank 771


Gene organization within MGE regions


Location: 1247271..1315723
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1A19_RS06520 (H1A19_06520) ciaH 1247271..1248584 (+) 1314 WP_000042580.1 cell wall metabolism sensor histidine kinase WalK Regulator
  H1A19_RS06525 (H1A19_06525) - 1248673..1249005 (+) 333 WP_000402075.1 putative DNA-binding protein -
  H1A19_RS06530 (H1A19_06530) ffh 1249023..1250588 (+) 1566 WP_000863589.1 signal recognition particle protein -
  H1A19_RS06535 (H1A19_06535) - 1250655..1251341 (+) 687 WP_000280308.1 SatD family protein -
  H1A19_RS06540 (H1A19_06540) - 1251331..1252104 (+) 774 WP_000622398.1 DUF3307 domain-containing protein -
  H1A19_RS06545 (H1A19_06545) - 1252137..1253798 (-) 1662 WP_000093960.1 peptide ABC transporter substrate-binding protein -
  H1A19_RS06550 (H1A19_06550) xerS 1254251..1255321 (+) 1071 WP_000817930.1 tyrosine recombinase XerS -
  H1A19_RS06555 (H1A19_06555) - 1255364..1256302 (-) 939 WP_000620981.1 HAMP domain-containing sensor histidine kinase -
  H1A19_RS06560 (H1A19_06560) - 1256299..1256967 (-) 669 WP_000076874.1 response regulator transcription factor -
  H1A19_RS06565 (H1A19_06565) - 1257077..1259032 (-) 1956 WP_000499553.1 FtsX-like permease family protein -
  H1A19_RS06570 (H1A19_06570) - 1259034..1259786 (-) 753 WP_000923535.1 ABC transporter ATP-binding protein -
  H1A19_RS06575 (H1A19_06575) - 1259812..1260774 (-) 963 WP_001253127.1 S41 family peptidase -
  H1A19_RS06580 (H1A19_06580) - 1260940..1261429 (+) 490 Protein_1226 PASTA domain-containing protein -
  H1A19_RS06585 (H1A19_06585) - 1261461..1262309 (-) 849 WP_000694283.1 MetQ/NlpA family ABC transporter substrate-binding protein -
  H1A19_RS06590 (H1A19_06590) - 1262442..1263185 (-) 744 WP_000559000.1 GNAT family N-acetyltransferase -
  H1A19_RS06595 (H1A19_06595) trmFO 1263263..1264597 (-) 1335 WP_181576315.1 methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO -
  H1A19_RS06600 (H1A19_06600) - 1264711..1265409 (-) 699 WP_000936162.1 GntR family transcriptional regulator -
  H1A19_RS06605 (H1A19_06605) guaA 1265622..1267184 (+) 1563 WP_000129872.1 glutamine-hydrolyzing GMP synthase -
  H1A19_RS06615 (H1A19_06615) - 1268315..1269442 (+) 1128 WP_000547446.1 cation:proton antiporter -
  H1A19_RS06620 (H1A19_06620) - 1269505..1270467 (-) 963 WP_000023418.1 DUF1002 domain-containing protein -
  H1A19_RS06625 (H1A19_06625) - 1270620..1271033 (-) 414 WP_000767937.1 VOC family protein -
  H1A19_RS06630 (H1A19_06630) - 1271049..1271792 (-) 744 WP_050881973.1 class A sortase -
  H1A19_RS06635 (H1A19_06635) gyrA 1271799..1274258 (-) 2460 WP_017644318.1 DNA gyrase subunit A -
  H1A19_RS06640 (H1A19_06640) - 1274497..1275486 (+) 990 WP_000127487.1 L-lactate dehydrogenase -
  H1A19_RS06645 (H1A19_06645) nox 1275607..1276977 (-) 1371 WP_000036813.1 H2O-forming NADH oxidase -
  H1A19_RS06650 (H1A19_06650) - 1277182..1278138 (-) 957 WP_000060306.1 ABC transporter permease -
  H1A19_RS06655 (H1A19_06655) - 1278140..1279201 (-) 1062 WP_000036988.1 ABC transporter permease -
  H1A19_RS06660 (H1A19_06660) - 1279194..1280729 (-) 1536 WP_181576316.1 ABC transporter ATP-binding protein -
  H1A19_RS06665 (H1A19_06665) - 1280874..1281923 (-) 1050 WP_001034779.1 BMP family protein -
  H1A19_RS06670 (H1A19_06670) - 1281988..1282377 (-) 390 WP_000526762.1 cytidine deaminase -
  H1A19_RS06675 (H1A19_06675) - 1282703..1283293 (-) 591 WP_000002661.1 class I SAM-dependent methyltransferase -
  H1A19_RS06680 (H1A19_06680) coaA 1283399..1284319 (+) 921 WP_001058331.1 type I pantothenate kinase -
  H1A19_RS06685 (H1A19_06685) rpsT 1284373..1284621 (+) 249 WP_001872296.1 30S ribosomal protein S20 -
  H1A19_RS06690 (H1A19_06690) - 1284705..1285538 (-) 834 WP_181576317.1 amino acid ABC transporter substrate-binding protein -
  H1A19_RS06695 (H1A19_06695) - 1285552..1286181 (-) 630 WP_000891276.1 amino acid ABC transporter ATP-binding protein -
  H1A19_RS06700 (H1A19_06700) - 1286191..1286832 (-) 642 WP_000120401.1 amino acid ABC transporter permease -
  H1A19_RS06705 (H1A19_06705) - 1286967..1287296 (-) 330 WP_000056777.1 zinc ribbon domain-containing protein YjdM -
  H1A19_RS06710 (H1A19_06710) - 1287475..1288608 (-) 1134 WP_000564846.1 ISAs1-like element IS1548 family transposase -
  H1A19_RS06715 (H1A19_06715) glmS 1288785..1290599 (-) 1815 WP_000334314.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -
  H1A19_RS06720 (H1A19_06720) lepB 1290868..1291425 (-) 558 WP_000240773.1 signal peptidase I -
  H1A19_RS06725 (H1A19_06725) pyk 1291596..1293098 (-) 1503 WP_001042781.1 pyruvate kinase -
  H1A19_RS06730 (H1A19_06730) pfkA 1293147..1294169 (-) 1023 WP_000820831.1 6-phosphofructokinase -
  H1A19_RS06735 (H1A19_06735) - 1294250..1297354 (-) 3105 WP_000457960.1 DNA polymerase III subunit alpha -
  H1A19_RS06740 (H1A19_06740) - 1297499..1297867 (+) 369 WP_000312256.1 GntR family transcriptional regulator -
  H1A19_RS06745 (H1A19_06745) - 1297868..1298566 (+) 699 WP_000192686.1 ABC transporter ATP-binding protein -
  H1A19_RS06750 (H1A19_06750) - 1298578..1299360 (+) 783 WP_000467138.1 hypothetical protein -
  H1A19_RS06755 (H1A19_06755) - 1299741..1300055 (+) 315 WP_000420682.1 YdcP family protein -
  H1A19_RS06760 (H1A19_06760) - 1300071..1300457 (+) 387 WP_000985015.1 YdcP family protein -
  H1A19_RS06765 (H1A19_06765) - 1300486..1301871 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  H1A19_RS06770 (H1A19_06770) - 1301874..1302026 (+) 153 WP_181576318.1 conjugal transfer protein -
  H1A19_RS06775 (H1A19_06775) mobT 1302049..1303254 (+) 1206 WP_000398284.1 MobT family relaxase -
  H1A19_RS06780 (H1A19_06780) - 1303297..1303518 (+) 222 WP_001009056.1 hypothetical protein -
  H1A19_RS06785 (H1A19_06785) - 1303635..1304132 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  H1A19_RS06790 (H1A19_06790) - 1304221..1304613 (+) 393 WP_000723888.1 conjugal transfer protein -
  H1A19_RS06795 (H1A19_06795) - 1304597..1307044 (+) 2448 WP_000331160.1 ATP-binding protein -
  H1A19_RS06800 (H1A19_06800) - 1307047..1309224 (+) 2178 Protein_1270 CD3337/EF1877 family mobilome membrane protein -
  H1A19_RS06805 (H1A19_06805) - 1309221..1310222 (+) 1002 WP_000769868.1 lysozyme family protein -
  H1A19_RS06810 (H1A19_06810) - 1310219..1311151 (+) 933 WP_001224319.1 conjugal transfer protein -
  H1A19_RS11260 - 1311465..1311512 (+) 48 Protein_1273 hypothetical protein -
  H1A19_RS06820 (H1A19_06820) tet(M) 1311528..1313447 (+) 1920 WP_000691727.1 tetracycline resistance ribosomal protection protein Tet(M) -
  H1A19_RS06825 (H1A19_06825) - 1313566..1313733 (+) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  H1A19_RS06830 (H1A19_06830) - 1313793..1314146 (-) 354 WP_001227346.1 helix-turn-helix transcriptional regulator -
  H1A19_RS06835 (H1A19_06835) - 1314651..1315073 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  H1A19_RS06840 (H1A19_06840) - 1315070..1315300 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -

Sequence

Protein


Download         Length: 437 a.a.        Molecular weight: 49708.14 Da        Isoelectric Point: 9.4961

>NTDB_id=469214 H1A19_RS06520 WP_000042580.1 1247271..1248584(+) (ciaH) [Streptococcus agalactiae strain BJ01]
MSKPIKISKFKKNVSDSHFIHFFTVFSGIFLVMTVIILQVMRYGVYSSVDSSLKYISTHPKNYINMVMSRTAAYLDNSNI
ASVKLKPGGQTVANTDIILFTSEEEVINYFDAFSNYQFLKPNKKNLGGISELTLTNIFGQDETYHAVTVKVNNPAYPNVT
YMTAIVNIDQLVNAKERYEKIIIFVMTTFWIISIGASIYLAKWAQKPIIENYERQKAFVENASHELRTPLAVLQNRLETL
FRKPNATILENSENIASSLDEVRNMRILTTNLLNLARRDDGIKPELAVIKPTLFDSIFENYDLITQENGKNFTGHNMIQD
SFKTDKTLLKQLMTILFDNAIKYTDNDGSIDFTISETDKYLFLEIADNGPGISEEDKVRIFDRFYRVDKARTRQQGGFGL
GLSLAQQIVNSLRGNITVIDNKPRGSIFKIKLPKVKG

Nucleotide


Download         Length: 1314 bp        

>NTDB_id=469214 H1A19_RS06520 WP_000042580.1 1247271..1248584(+) (ciaH) [Streptococcus agalactiae strain BJ01]
ATGTCGAAACCGATTAAGATAAGTAAATTCAAAAAAAATGTCTCAGATAGTCATTTTATCCATTTTTTCACAGTTTTTAG
TGGTATTTTTCTGGTTATGACTGTTATCATCCTCCAAGTCATGCGCTATGGTGTTTATTCTTCTGTTGATAGTAGTTTAA
AGTATATCAGTACCCATCCTAAAAATTACATCAATATGGTTATGTCACGTACTGCTGCCTACCTAGATAACTCCAATATC
GCAAGTGTCAAGTTAAAACCCGGCGGTCAGACAGTAGCTAATACTGATATTATTCTTTTTACATCAGAAGAAGAAGTCAT
TAACTATTTTGACGCATTTTCAAACTATCAGTTTTTAAAACCTAATAAAAAAAATCTAGGTGGCATTAGTGAATTAACTT
TAACCAACATCTTTGGTCAAGATGAGACATATCATGCTGTCACCGTAAAAGTTAATAACCCTGCTTATCCTAATGTGACT
TACATGACAGCTATTGTTAATATTGATCAATTAGTAAATGCTAAAGAACGCTATGAAAAAATTATTATATTTGTCATGAC
TACTTTTTGGATTATTTCAATTGGAGCAAGTATCTACTTAGCTAAATGGGCACAAAAACCGATTATAGAAAACTACGAAA
GACAGAAGGCTTTTGTCGAAAATGCTAGCCACGAGCTGCGTACTCCCCTAGCTGTCTTACAAAATCGCCTAGAAACGCTA
TTCAGAAAACCGAATGCCACCATTTTAGAAAATAGTGAAAATATCGCTTCAAGTCTAGATGAAGTACGAAATATGCGTAT
TTTAACCACTAATCTTTTAAACTTAGCAAGACGTGATGATGGAATCAAACCAGAATTAGCTGTTATTAAGCCTACACTTT
TTGATAGTATCTTTGAGAATTATGATCTAATCACCCAAGAGAATGGTAAAAATTTTACTGGACATAATATGATCCAAGAT
AGTTTCAAAACAGATAAGACACTGCTAAAACAACTCATGACTATTTTATTTGATAATGCTATAAAATATACTGACAATGA
TGGTAGCATTGACTTTACCATATCTGAAACTGATAAGTATCTCTTTTTAGAAATCGCTGATAATGGACCAGGAATTTCAG
AGGAGGATAAAGTCAGAATTTTTGATCGTTTTTACCGTGTTGACAAAGCAAGAACACGACAACAAGGAGGGTTTGGCCTC
GGCCTTTCTTTAGCTCAACAAATCGTTAACTCACTGCGAGGTAATATTACAGTAATTGATAATAAACCTAGAGGCAGTAT
TTTTAAGATAAAACTACCAAAAGTAAAAGGTTAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(216-281)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

60.14

98.169

0.59
  ciaH Streptococcus pneumoniae Rx1

51.781

96.339

0.499
  ciaH Streptococcus pneumoniae D39

51.781

96.339

0.499
  ciaH Streptococcus pneumoniae R6

51.781

96.339

0.499
  ciaH Streptococcus pneumoniae TIGR4

51.781

96.339

0.499