Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6J83_RS19665 Genome accession   NZ_CP069549
Coordinates   4119146..4119805 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain FDAARGOS_1253     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4114146..4124805
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J83_RS19640 (I6J83_19640) - 4114888..4115835 (+) 948 WP_001305106.1 iron-siderophore ABC transporter substrate-binding protein -
  I6J83_RS19645 (I6J83_19645) - 4115832..4116719 (+) 888 WP_000614960.1 MurR/RpiR family transcriptional regulator -
  I6J83_RS19650 (I6J83_19650) ygiN 4116764..4117078 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  I6J83_RS19655 (I6J83_19655) mdaB 4117109..4117690 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  I6J83_RS19660 (I6J83_19660) qseC 4117800..4119149 (-) 1350 WP_000673367.1 quorum sensing histidine kinase QseC -
  I6J83_RS19665 (I6J83_19665) ciaR 4119146..4119805 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  I6J83_RS19670 (I6J83_19670) ygiW 4119957..4120349 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  I6J83_RS19675 (I6J83_19675) ygiV 4120402..4120884 (+) 483 WP_000183508.1 GyrI-like domain-containing protein -
  I6J83_RS19680 (I6J83_19680) ygiS 4120993..4122600 (+) 1608 WP_001338033.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=468069 I6J83_RS19665 WP_001221493.1 4119146..4119805(-) (ciaR) [Escherichia coli strain FDAARGOS_1253]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=468069 I6J83_RS19665 WP_001221493.1 4119146..4119805(-) (ciaR) [Escherichia coli strain FDAARGOS_1253]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAAGCGCTATATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACTGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TAGACCCTGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365