Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   SARLGA251_RS00195 Genome accession   NC_017349
Coordinates   45878..47227 (-) Length   449 a.a.
NCBI ID   WP_000806246.1    Uniprot ID   -
Organism   Staphylococcus aureus subsp. aureus LGA251     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 35681..47227 45878..47227 within 0


Gene organization within MGE regions


Location: 35681..47227
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SARLGA251_RS00140 (SARLGA251_00260) mecC 35681..37678 (-) 1998 WP_000725529.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC -
  SARLGA251_RS00145 (SARLGA251_00270) - 37779..39533 (+) 1755 WP_000941320.1 BlaR1 family beta-lactam sensor/signal transducer -
  SARLGA251_RS00150 (SARLGA251_00280) mecI 39530..39904 (+) 375 WP_000196386.1 mecC-type methicillin resistance repressor MecI -
  SARLGA251_RS14600 - 39978..40154 (-) 177 WP_158306650.1 hypothetical protein -
  SARLGA251_RS00155 (SARLGA251_00290) - 40160..40462 (-) 303 WP_000073847.1 hypothetical protein -
  SARLGA251_RS00160 (SARLGA251_00300) - 40482..40949 (-) 468 WP_000932101.1 hypothetical protein -
  SARLGA251_RS00165 (SARLGA251_00310) - 40966..41850 (-) 885 WP_000373152.1 HTH domain-containing protein -
  SARLGA251_RS00170 (SARLGA251_00320) - 42020..42466 (-) 447 WP_000659043.1 JAB domain-containing protein -
  SARLGA251_RS00175 (SARLGA251_00330) - 42487..42993 (-) 507 WP_001179666.1 DUF1643 domain-containing protein -
  SARLGA251_RS00180 (SARLGA251_00340) - 43009..43320 (-) 312 WP_001046053.1 DUF960 family protein -
  SARLGA251_RS00185 (SARLGA251_00350) - 43416..43754 (-) 339 WP_000171558.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SARLGA251_RS00190 (SARLGA251_00360) ccrB 44229..45857 (-) 1629 WP_001186597.1 cassette chromosome recombinase CcrB Machinery gene
  SARLGA251_RS00195 (SARLGA251_00370) ccrA 45878..47227 (-) 1350 WP_000806246.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52155.87 Da        Isoelectric Point: 10.0227

>NTDB_id=46581 SARLGA251_RS00195 WP_000806246.1 45878..47227(-) (ccrA) [Staphylococcus aureus subsp. aureus LGA251]
MKQAIGYLRQSTLKQQSLSAQKQTIKTLAEKHNIQHIIFYSDKQSGRTENRTGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQTYHVHILSVHDGYFDMNKAFDRLKLNIFISLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYH
NGTFMINNIEAPTVKAVFSYYLQGYGYKKIAQYLEDDEKFINRKPYQVRNIIMNPNYCGRVINQYGRYDNMCPSIVSTSI
YEQAQAIRSQKQLKRTSSANQLKQKIKCPYCGSTLTNITIRKKHRTLRYYVCPQNMNASRFVCEFKGINAQSLEASVLVT
CQDFFQNQHLYSKINHTIQKRLKKQKDIEAKSTVTQEQLIEKLAQGKIDAETFREQTQSFRQQSKPITSIHTHQIQKALQ
NVIQQSFTLNMLYPYIDEIHITKSKTLTGIYFKNEPLNIVNQTAQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=46581 SARLGA251_RS00195 WP_000806246.1 45878..47227(-) (ccrA) [Staphylococcus aureus subsp. aureus LGA251]
ATGAAACAAGCAATAGGTTATCTACGTCAAAGTACACTCAAGCAACAATCACTCTCGGCTCAGAAACAAACCATCAAGAC
ATTAGCCGAAAAACATAATATTCAACACATCATCTTTTATAGCGATAAGCAATCAGGACGTACTGAAAATCGAACAGGCT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATGTGACGTATTATGTTGCTATCGTCTGAATCGACTTCATCGTAAT
CTAAAAAATGCATTAAAACTCATGAAATTATGTCAAACGTATCATGTTCATATCTTAAGTGTTCATGATGGCTACTTCGA
CATGAATAAAGCTTTCGATCGACTAAAACTCAACATTTTCATCAGCTTGGCTGAACTAGAATCAGATAATATTGGAGAAC
AAGTCAAAAATGGCCTTCGGGAAAAAGCAAAACAAGGTAAACTGATTACGACCCATGCACCCTTTGGCTATCACTATCAT
AACGGTACTTTCATGATAAACAACATAGAAGCACCAACCGTAAAAGCTGTATTTAGCTATTATCTTCAAGGCTATGGTTA
TAAAAAAATTGCACAGTACTTAGAAGATGACGAGAAATTCATCAATCGTAAACCCTATCAAGTACGTAATATTATCATGA
ACCCCAATTATTGTGGTCGAGTCATTAATCAATACGGGCGATATGACAACATGTGTCCTTCTATTGTTTCGACAAGTATA
TATGAACAAGCTCAAGCGATACGGTCACAAAAGCAACTCAAACGGACATCATCAGCTAATCAACTCAAACAAAAAATTAA
ATGTCCTTATTGTGGTTCAACGTTGACTAATATAACCATTAGAAAAAAGCACCGCACATTACGTTATTATGTCTGTCCCC
AAAATATGAATGCATCTCGTTTTGTCTGTGAATTCAAAGGAATCAACGCACAATCATTAGAAGCGAGTGTCTTAGTTACA
TGTCAAGACTTCTTTCAAAATCAACATCTGTATTCAAAAATCAACCATACAATCCAAAAACGACTCAAAAAACAAAAAGA
CATAGAAGCTAAAAGTACAGTCACGCAAGAACAACTGATAGAAAAATTAGCCCAAGGTAAAATTGATGCAGAAACATTCA
GAGAACAAACGCAATCATTTCGACAACAGTCAAAACCTATAACATCAATCCATACGCATCAAATTCAAAAGGCTTTACAA
AATGTAATACAGCAAAGTTTCACGTTAAACATGTTGTACCCTTACATCGATGAAATTCATATTACCAAAAGTAAAACGCT
TACGGGTATCTATTTCAAAAATGAACCCTTAAACATCGTCAATCAAACAGCACAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

83.964

100

0.84
  ccrA Staphylococcus aureus N315

77.506

100

0.775

Multiple sequence alignment