Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   SARLGA251_RS00190 Genome accession   NC_017349
Coordinates   44229..45857 (-) Length   542 a.a.
NCBI ID   WP_001186597.1    Uniprot ID   -
Organism   Staphylococcus aureus subsp. aureus LGA251     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 35681..47227 44229..45857 within 0


Gene organization within MGE regions


Location: 35681..47227
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SARLGA251_RS00140 (SARLGA251_00260) mecC 35681..37678 (-) 1998 WP_000725529.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecC -
  SARLGA251_RS00145 (SARLGA251_00270) - 37779..39533 (+) 1755 WP_000941320.1 BlaR1 family beta-lactam sensor/signal transducer -
  SARLGA251_RS00150 (SARLGA251_00280) mecI 39530..39904 (+) 375 WP_000196386.1 mecC-type methicillin resistance repressor MecI -
  SARLGA251_RS14600 - 39978..40154 (-) 177 WP_158306650.1 hypothetical protein -
  SARLGA251_RS00155 (SARLGA251_00290) - 40160..40462 (-) 303 WP_000073847.1 hypothetical protein -
  SARLGA251_RS00160 (SARLGA251_00300) - 40482..40949 (-) 468 WP_000932101.1 hypothetical protein -
  SARLGA251_RS00165 (SARLGA251_00310) - 40966..41850 (-) 885 WP_000373152.1 HTH domain-containing protein -
  SARLGA251_RS00170 (SARLGA251_00320) - 42020..42466 (-) 447 WP_000659043.1 JAB domain-containing protein -
  SARLGA251_RS00175 (SARLGA251_00330) - 42487..42993 (-) 507 WP_001179666.1 DUF1643 domain-containing protein -
  SARLGA251_RS00180 (SARLGA251_00340) - 43009..43320 (-) 312 WP_001046053.1 DUF960 family protein -
  SARLGA251_RS00185 (SARLGA251_00350) - 43416..43754 (-) 339 WP_000171558.1 SAUGI family uracil-DNA glycosylase inhibitor -
  SARLGA251_RS00190 (SARLGA251_00360) ccrB 44229..45857 (-) 1629 WP_001186597.1 cassette chromosome recombinase CcrB Machinery gene
  SARLGA251_RS00195 (SARLGA251_00370) ccrA 45878..47227 (-) 1350 WP_000806246.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62331.03 Da        Isoelectric Point: 9.6454

>NTDB_id=46580 SARLGA251_RS00190 WP_001186597.1 44229..45857(-) (ccrB) [Staphylococcus aureus subsp. aureus LGA251]
MQQLKQKRVGIYVRVSTEMQSTEGYSIDGQINQIREYCNFNNFAVVDVYADRGISGKSMNRPELQRLLKDANEGQIDCVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYITKKGKPFSISSITYILSNPFYIGKIQFAK
YKDWNEKRRKGLNDKPIIADGKHSPIISQDLWDKVQARKQQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSIRADVIEKYVMDQIREIVKSDTVIQQVVERVNQENQVDVAALNHDIAYKQQQFD
EVNAKIKNLVQTIDDNPDLTSAIKPTIHQYEAQLNDITNQMNQLKHQQNQEKPSYDSKQIAVLLQRIFQNITSMDKTQLK
ALYLTVIDRIDIRKDGDHKKQFYVTLKLNNEIIKQLFNNTALDEVLLSTSSLFLPQTLYFQI

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=46580 SARLGA251_RS00190 WP_001186597.1 44229..45857(-) (ccrB) [Staphylococcus aureus subsp. aureus LGA251]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCGACAGAAATGCAGAGTACTGAAGGATATAGTAT
CGACGGACAAATCAATCAAATCAGAGAATACTGTAATTTCAATAACTTCGCAGTTGTAGATGTATACGCGGATAGAGGAA
TCTCTGGAAAATCTATGAACCGCCCAGAATTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATCGATTGTGTCATG
GTATATAAAACGAATCGCCTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTTGA
ATTTTTTAGCTTGTCTGAACGTATGGAGGTCAATACTTCTTCTGGTAAACTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAAAACGTATTCATGGGCCAAACCAGACGCGCCCAAGAAGGCTATTATCAAGGAAAT
TTGCCGCTAGGATACGATAAAATACCAGATAGTAAACACGAACTGATGATTAATCAACATGAAGCCAATATTGTAAAATA
TATTTTCGAGTCTTATGCCAAAGGGCATGGCTATCGTAAAATTGCCAATGCACTCAATCACAAAGGTTACATCACTAAAA
AAGGGAAACCTTTCAGTATCAGTTCTATTACTTATATTCTATCCAATCCGTTCTACATTGGTAAAATTCAATTTGCGAAG
TACAAAGATTGGAATGAAAAACGTCGTAAAGGCCTGAATGATAAACCAATCATAGCTGACGGTAAGCATTCCCCTATTAT
TAGCCAAGACTTATGGGATAAAGTCCAAGCACGTAAACAACAAGTCAGTCAAAAACCACAAGTTCACGGTAAAGGAACCA
ATCTATTAACCGGTATCGTTCACTGTCCGCAGTGCGGTGCACCTATGGCCGCAAGCAACACCACTAATACACTCAAAGAT
GGAACTAAGAAACGTATTCGCTATTATTCTTGTAGTAACTTTCGCAACAAAGGATCAAAAGTATGTTCAGCCAATAGTAT
TAGAGCCGATGTCATCGAAAAATATGTCATGGATCAAATACGCGAAATTGTCAAAAGTGATACAGTTATACAACAGGTTG
TCGAACGTGTCAATCAAGAGAATCAAGTCGATGTAGCTGCACTCAATCATGATATTGCTTACAAACAACAACAATTTGAT
GAAGTAAACGCTAAAATAAAAAATCTTGTTCAAACCATCGATGATAATCCAGACTTAACGTCTGCAATCAAACCAACGAT
TCATCAATATGAAGCACAACTGAATGACATTACAAATCAAATGAATCAACTCAAGCACCAACAAAATCAAGAGAAACCAT
CTTATGATTCAAAACAAATCGCTGTCTTATTACAACGCATATTTCAAAACATAACATCCATGGATAAAACACAACTCAAA
GCATTGTACCTTACGGTTATTGACCGTATTGATATTCGTAAAGATGGGGATCATAAAAAGCAATTCTATGTCACACTCAA
GCTCAATAATGAGATTATTAAACAACTTTTCAATAATACCGCTCTAGACGAAGTGCTCCTCAGCACTTCGTCTTTGTTTT
TGCCTCAAACACTCTACTTTCAAATCTAA

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(301-356)

Resolvase, N terminal domain (Resolvase)

(11-156)

Recombinase (Recombinase)

(180-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

86.531

100

0.865

Multiple sequence alignment