Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I5P61_RS03895 Genome accession   NZ_CP066743
Coordinates   789496..790155 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain UPEC 536     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 784496..795155
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I5P61_RS03870 (I5P61_00763) - 785238..786185 (+) 948 WP_001296418.1 iron-siderophore ABC transporter substrate-binding protein -
  I5P61_RS03875 (I5P61_00764) - 786182..787069 (+) 888 WP_000614943.1 MurR/RpiR family transcriptional regulator -
  I5P61_RS03880 (I5P61_00765) ygiN 787114..787428 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  I5P61_RS03885 (I5P61_00766) mdaB 787459..788040 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  I5P61_RS03890 (I5P61_00767) qseC 788150..789499 (-) 1350 WP_000673368.1 quorum sensing histidine kinase QseC -
  I5P61_RS03895 (I5P61_00768) ciaR 789496..790155 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  I5P61_RS03900 (I5P61_00769) ygiW 790307..790699 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  I5P61_RS03905 (I5P61_00770) ygiV 790752..791234 (+) 483 WP_000183492.1 GyrI-like domain-containing protein -
  I5P61_RS03910 (I5P61_00771) ygiS 791343..792950 (+) 1608 WP_011579205.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=455872 I5P61_RS03895 WP_001221493.1 789496..790155(-) (ciaR) [Escherichia coli strain UPEC 536]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=455872 I5P61_RS03895 WP_001221493.1 789496..790155(-) (ciaR) [Escherichia coli strain UPEC 536]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGCCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACACTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365