Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   I6H78_RS01680 Genome accession   NZ_CP066059
Coordinates   352567..353904 (-) Length   445 a.a.
NCBI ID   WP_198459739.1    Uniprot ID   -
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 347567..358904
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS01655 (I6H78_01655) rpiA 348239..348922 (-) 684 WP_198459735.1 ribose-5-phosphate isomerase RpiA -
  I6H78_RS01660 (I6H78_01660) - 349028..349957 (-) 930 WP_084851842.1 peptidase U32 family protein -
  I6H78_RS01665 (I6H78_01665) - 350083..350763 (-) 681 WP_198459736.1 ABC transporter ATP-binding protein -
  I6H78_RS01670 (I6H78_01670) - 350777..351832 (-) 1056 WP_198459737.1 ABC transporter permease -
  I6H78_RS01675 (I6H78_01675) - 352218..352502 (+) 285 WP_198459738.1 DUF3270 domain-containing protein -
  I6H78_RS01680 (I6H78_01680) ciaH 352567..353904 (-) 1338 WP_198459739.1 sensor histidine kinase Regulator
  I6H78_RS01685 (I6H78_01685) ciaR 353894..354568 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  I6H78_RS01690 (I6H78_01690) - 354678..357224 (-) 2547 WP_198459740.1 M1 family metallopeptidase -
  I6H78_RS01695 (I6H78_01695) - 357345..357785 (-) 441 WP_198459741.1 ASCH domain-containing protein -
  I6H78_RS01700 (I6H78_01700) - 357782..358630 (-) 849 WP_198459742.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50762.42 Da        Isoelectric Point: 9.4710

>NTDB_id=453408 I6H78_RS01680 WP_198459739.1 352567..353904(-) (ciaH) [Streptococcus oralis strain FDAARGOS_1021]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRIFEYENQI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=453408 I6H78_RS01680 WP_198459739.1 352567..353904(-) (ciaH) [Streptococcus oralis strain FDAARGOS_1021]
ATGTTCAATAAACTAAAAAAAACATGGTATGCAGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCGATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTTGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCGGTTATACAGTTAGCCCTGAATCGGGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACA
GCGGATGCTAGCAAGGCTGAAATCAAACCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGCTTTTTAGGCTTGGACAAGATCAAACTGGACAAGAAAGAGTTGAATCATATTCGCCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTATCGGATGATCTTGATGGAAACCAATTCTTCATCCGTGTCAAGCAAT
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTATTTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTCGAAAATGCCAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGCAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATTGCTTCCAGTCTTGAAGAAGTTCGTAACAT
GCGCTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATTAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACGACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCAGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTATTTGACAATGCCATCAAGTATACTGA
AGAAGATGGCAAGATTGAGTTTGTGGTCCATGCTACAGATCGCCATCTCTATCTAACAGTAACAGATAATGGGATTGGAA
TCTCAGCTGCCGATAAGAAGAAAATCTTTGACCGATTTTATCGTGTAGACAAGGCGAGAACCCGTCAGAAAGGTGGCTTT
GGTTTGGGACTTTCTTTGGCCAAGCAAATCGTAGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCCAGAGG
AACAATTTTTGAAGTTAAGATTGCCATCCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae D39

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae R6

83.973

99.551

0.836
  ciaH Streptococcus pneumoniae TIGR4

83.973

99.551

0.836
  ciaH Streptococcus mutans UA159

55.023

98.427

0.542