Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   I6H72_RS06770 Genome accession   NZ_CP066055
Coordinates   1353919..1355865 (+) Length   648 a.a.
NCBI ID   WP_020998097.1    Uniprot ID   U2XXQ8
Organism   Streptococcus constellatus strain FDAARGOS_1015     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1348919..1360865
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H72_RS06750 (I6H72_06750) argR 1349469..1349909 (+) 441 WP_198457735.1 arginine repressor -
  I6H72_RS06755 (I6H72_06755) hexA 1350072..1352630 (+) 2559 WP_020998099.1 DNA mismatch repair protein MutS Machinery gene
  I6H72_RS06760 (I6H72_06760) - 1352771..1353235 (-) 465 Protein_1319 DUF3021 domain-containing protein -
  I6H72_RS06765 (I6H72_06765) - 1353232..1353660 (-) 429 WP_232619561.1 LytTR family DNA-binding domain-containing protein -
  I6H72_RS06770 (I6H72_06770) hexB 1353919..1355865 (+) 1947 WP_020998097.1 DNA mismatch repair endonuclease MutL Machinery gene
  I6H72_RS06775 (I6H72_06775) ruvA 1356251..1356841 (+) 591 WP_006269179.1 Holliday junction branch migration protein RuvA Machinery gene
  I6H72_RS06780 (I6H72_06780) - 1356852..1357415 (+) 564 WP_187327920.1 DNA-3-methyladenine glycosylase I -
  I6H72_RS06785 (I6H72_06785) - 1357553..1357967 (-) 415 Protein_1324 EamA family transporter -
  I6H72_RS06790 (I6H72_06790) - 1358128..1358983 (-) 856 Protein_1325 helix-turn-helix domain-containing protein -
  I6H72_RS06795 (I6H72_06795) - 1359366..1359635 (+) 270 WP_232619562.1 bacteriocin, lactococcin 972 family protein -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73362.53 Da        Isoelectric Point: 5.1034

>NTDB_id=453346 I6H72_RS06770 WP_020998097.1 1353919..1355865(+) (hexB) [Streptococcus constellatus strain FDAARGOS_1015]
MSKIIELPENLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEVGLKSIQVIDNGEGIEHEEVSLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSRLTIETATNGGTHGTRLIAQGGEIETVEPSSCPKGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDMINRLSLAHPEVAFILLNDGKELTRTAGTGNLRQAIAGIYGLTTAKKMIEISASNLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIAIQIDPYLADVNVHPTKQEVRISKERELMVLISQ
AIAASLKEQDLIPDALENLAKSTINRANKSEQTSLPLKENRLYYDKERNDFFVRPQVSESNLPFEENATFDQQHTDTDML
ASRAVSVKFAARQTPSYDQLDHPELDQSSLERALDKLDGEETSTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYREKIGDVDDSQQQLLVPYIFEFPADDMLRLKQRMNLLEEVGVFLDEYGSNQFILREYPIWMKEEEIESGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDNDSARDLIFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=453346 I6H72_RS06770 WP_020998097.1 1353919..1355865(+) (hexB) [Streptococcus constellatus strain FDAARGOS_1015]
ATGTCAAAAATTATAGAATTACCAGAAAATCTTGCTAATCAGATTGCGGCTGGTGAGGTCATCGAGCGACCTAGCAGCGT
GGTCAAGGAGTTGATAGAGAATTCCATTGATGCTGGTGCCACTCAAATTATAGTTGAGATTGAAGAAGTAGGGCTCAAGA
GTATTCAAGTCATCGATAATGGTGAAGGAATTGAGCATGAGGAGGTTTCCTTGGCTTTGCGGCGGCACGCAACGAGTAAA
ATTAAGAAGCAAGCCGATCTTTTTCGGATTCGGACTTTAGGCTTTCGTGGTGAAGCGCTTCCGTCTATTGCTTCTGTTTC
ACGCTTGACAATTGAAACTGCGACAAATGGTGGAACACATGGGACGCGTTTAATTGCTCAGGGGGGAGAAATTGAAACTG
TGGAACCAAGTAGTTGCCCTAAGGGTACCAAAATCAAAGTGGAAGACCTTTTTTTCAACACGCCTGCTCGCTTGAAATAT
ATGAAAAGTCAGCAAGCAGAACTATCTCACATTGTAGATATGATTAACCGTTTGAGCTTAGCTCATCCAGAGGTCGCTTT
TATCTTGCTCAATGATGGTAAAGAGTTGACTCGGACAGCAGGAACAGGAAATTTGCGTCAAGCAATTGCTGGTATCTATG
GATTAACAACAGCAAAAAAAATGATTGAAATTTCAGCTTCTAATTTGGATTTTGAAGTATCAGGCTATATTAGTCTACCA
GAGTTGACGCGTGCCAATCGTAACTACATCACCATTCTCATCAATGGTCGTTACATCAAGAACTTCCTGCTCAATCGAGC
TATTCTTGATGGTTACGGTAGTAAGCTCATGGTTGGGCGATTCCCGATTGCTGTGATTGCTATCCAGATTGATCCTTACC
TTGCGGATGTTAATGTTCATCCGACCAAGCAAGAAGTGCGGATTTCCAAGGAGCGAGAACTGATGGTCTTGATTTCGCAA
GCTATTGCTGCGAGTTTAAAAGAACAGGATTTGATTCCGGATGCTTTGGAGAATTTAGCAAAATCAACCATTAACAGAGC
AAATAAGTCGGAGCAGACGAGCCTTCCGCTCAAAGAAAACCGACTCTATTATGACAAAGAGAGAAATGACTTTTTTGTTA
GACCTCAAGTATCAGAAAGCAATCTTCCTTTTGAGGAAAATGCTACATTTGATCAGCAGCATACTGATACAGATATGCTT
GCTTCCAGAGCAGTTTCTGTCAAATTTGCAGCAAGGCAAACTCCTTCTTACGATCAACTAGATCATCCAGAACTGGATCA
GTCAAGCTTAGAAAGAGCTTTAGATAAGTTAGATGGAGAAGAAACTTCAACTTTTCCAGAACTGGAATATTTCGGGCAAA
TGCATGGCACGTACCTCTTTGCACAAGGAAATGGTGGTCTCTATATTATCGACCAGCATGCAGCGCAGGAGCGAGTCAAA
TATGAGTATTATCGGGAAAAAATCGGTGATGTGGATGACAGTCAGCAGCAACTTTTGGTTCCCTATATCTTTGAATTTCC
AGCGGACGATATGCTGCGGCTCAAGCAGCGGATGAATCTGCTGGAAGAAGTCGGAGTTTTCTTGGACGAATACGGCAGCA
ATCAGTTTATTCTGAGGGAATACCCTATCTGGATGAAGGAAGAGGAAATCGAGTCGGGTATCTATGAGATGTGTGATATG
CTGCTCCTTACCAAGGAAGTTTCTATCAAGAAATACCGAGCTGAACTAGCGATTATGATGAGTTGCAAACGCTCTATTAA
GGCCAATCATAGCTTAGATAATGATTCGGCACGTGATTTGATCTTCCAGTTATCGCAATGTGACAATCCCTACAATTGCC
CTCACGGTCGTCCAGTTTTGGTAAACTTTACCAAATCTGATATGGAAAAAATGTTCCGTCGCATTCAGGAAAACCACACC
AGCTTGCGAGAATTGGGCAAGTATTGA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-119)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2XXQ8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

75.767

100

0.762