Detailed information NTG0453345

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: I6H72_RS06755
• Genome accession: NZ_CP066055
• Coordinates: 1350072..1352630 (+)
• Length: 852 a.a.
• NCBI ID: WP_020998099.1
• Uniprot ID: U2ZHI0
• Organism: Streptococcus constellatus strain FDAARGOS_1015
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1345072..1357630

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H72_RS06735 (I6H72_06735)	-	1346582..1347091 (+)	510	WP_198457733.1	hypothetical protein	-
I6H72_RS06740 (I6H72_06740)	nrdI	1347167..1347622 (+)	456	WP_003032317.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
I6H72_RS06745 (I6H72_06745)	argS	1347677..1349365 (-)	1689	WP_198457734.1	arginine--tRNA ligase	-
I6H72_RS06750 (I6H72_06750)	argR	1349469..1349909 (+)	441	WP_198457735.1	arginine repressor	-
I6H72_RS06755 (I6H72_06755)	hexA	1350072..1352630 (+)	2559	WP_020998099.1	DNA mismatch repair protein MutS	Machinery gene
I6H72_RS06760 (I6H72_06760)	-	1352771..1353235 (-)	465	Protein_1319	DUF3021 domain-containing protein	-
I6H72_RS06765 (I6H72_06765)	-	1353232..1353660 (-)	429	WP_232619561.1	LytTR family DNA-binding domain-containing protein	-
I6H72_RS06770 (I6H72_06770)	hexB	1353919..1355865 (+)	1947	WP_020998097.1	DNA mismatch repair endonuclease MutL	Machinery gene
I6H72_RS06775 (I6H72_06775)	ruvA	1356251..1356841 (+)	591	WP_006269179.1	Holliday junction branch migration protein RuvA	Machinery gene
I6H72_RS06780 (I6H72_06780)	-	1356852..1357415 (+)	564	WP_187327920.1	DNA-3-methyladenine glycosylase I	-

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95972.41 Da
• Isoelectric Point: 4.9979

>NTDB_id=453345 I6H72_RS06755 WP_020998099.1 1350072..1352630(+) (hexA) [Streptococcus constellatus strain FDAARGOS_1015]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAINAAQILEIALTSRNKNSENPIPMAGVPYHSVQQYIDVLI
ESGYKVAIAEQVEDPKKAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVALDKLENLYGLAYMDLVTGEFQVTSLSDFNM
VCGEIRNLRAREVVLGYELPESEHQVLANQMNLLLSQVGTAFEDVQLLGDELSRLEHQVAGKLLEYVHQTQLRELSHLKR
VHHYEIKDFLQMDYATMASLDLTENARTGKKHGSLYWLMDETKTAMGTRLLRRWIQQPLIDKERILKRQDVVQVFLDHFF
ERSDLADSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSNVPQIKGILQGIDHPVLGQLIENLDDIPELANLIQSAISP
DAPNVITEGNIIQTGFDETLDKYRVVMRDGTSWIADIEAKERAASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIKRLQSLAQTLATIDVLQSFAAVAEKQRFVRPEFI
ERPSIEIDKGRHAVVEKVMGAQTYIPNSISMDENVNVQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVSAESAQLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANHAISQATEHSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TDLSTSLTQLENVHVATLEKDGQVTFLHKIEAGPADKSYGIHVAKIAGLPNDLLMRADQILTRLEEQANEKPSLNPSNKG
ANDSKENQVSEQISLFTETTESPVLEKLRQLDIYNMTPMEVMLAVAEMKKHL

Nucleotide

• Length: 2559 bp

>NTDB_id=453345 I6H72_RS06755 WP_020998099.1 1350072..1352630(+) (hexA) [Streptococcus constellatus strain FDAARGOS_1015]
ATGACAAAAGAAAAACTATCTCCGGGAATGCAACAGTATTTAGATATAAAAAAAGATTATCCGGATGCTTTTTTGCTATT
TCGCATGGGAGATTTTTATGAATTATTCTATGAAGATGCGATCAATGCAGCACAGATTTTAGAAATTGCTCTGACTAGCC
GTAATAAAAATTCGGAAAATCCAATCCCGATGGCAGGAGTTCCCTACCATTCGGTGCAACAGTATATTGATGTTTTAATT
GAATCGGGCTATAAAGTAGCGATTGCAGAGCAGGTGGAAGATCCTAAAAAAGCAGTTGGTGTAGTCAAACGTGAGGTGGT
ACAAGTCATCACACCGGGGACAGTCGTTGATTCTTCAAAACCAGATAGTCAAAATAATTTCTTGGTAGCTTTAGATAAAC
TAGAAAATTTATATGGGCTGGCTTACATGGACTTGGTTACAGGTGAATTTCAGGTCACAAGTCTTAGTGACTTTAACATG
GTCTGTGGAGAAATTCGGAACTTGCGAGCGCGTGAAGTGGTCTTAGGATATGAATTACCTGAATCAGAGCACCAAGTGTT
GGCAAATCAAATGAATTTGTTATTATCACAGGTGGGAACTGCTTTTGAAGATGTTCAGCTATTAGGGGATGAATTGTCTC
GCTTAGAACATCAAGTAGCTGGAAAACTGTTAGAATATGTTCATCAGACGCAGCTGCGTGAGCTTAGTCACTTAAAGCGA
GTTCATCATTATGAAATCAAGGATTTCTTACAGATGGATTATGCAACCATGGCAAGTCTGGATTTAACAGAGAATGCACG
TACAGGAAAGAAGCACGGTAGTCTGTATTGGCTGATGGATGAGACCAAGACAGCTATGGGAACGCGACTTTTAAGAAGAT
GGATTCAGCAGCCCTTGATTGACAAAGAGCGAATCCTTAAGCGGCAGGATGTCGTACAAGTCTTTTTAGATCATTTTTTT
GAGCGCAGTGATTTAGCAGATAGTCTCAAAGGTGTGTATGACATTGAGCGTTTAGCTAGTCGTGTTTCGTTTGGAAAGAC
CAATCCGAAAGATTTATTGCAGTTGGCGGCAACATTGAGCAATGTCCCTCAGATTAAGGGAATTTTACAAGGAATTGATC
ATCCTGTTTTGGGACAGTTGATTGAAAACTTGGATGACATTCCAGAATTGGCAAACTTGATTCAGTCGGCGATTTCTCCC
GATGCTCCAAATGTTATTACTGAAGGGAATATCATTCAAACTGGTTTTGATGAAACCTTAGATAAGTATCGAGTGGTTAT
GCGAGATGGTACGAGCTGGATTGCTGATATCGAAGCGAAAGAAAGGGCGGCTAGTGGGATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTCCATGTCACTAATTCACAGTTGGAGCACGTACCTAGCCACTTTTTCCGAAAAGCA
ACGTTGAAAAATTCAGAACGATTTGGTACAGAGGAATTGGCTCGTATTGAAGGCGAAATGTTGGAAGCGCGTGAAAAATC
TGCTAATTTAGAATATGAGATTTTTATGCGTATTCGTGAAGAAGCTGGCAAATATATCAAGCGTCTGCAATCCTTGGCAC
AAACTCTGGCAACGATTGATGTATTACAAAGTTTTGCAGCAGTTGCTGAAAAGCAACGCTTTGTACGCCCAGAATTTATT
GAACGTCCTTCCATTGAAATTGATAAGGGACGGCATGCGGTTGTAGAAAAGGTCATGGGTGCACAAACCTATATTCCTAA
CAGCATTTCAATGGATGAAAATGTCAACGTTCAGCTAATTACAGGTCCAAATATGAGTGGGAAGTCAACCTATATGCGTC
AATTAGCGATTATTGTTATTATGGCTCAAATGGGTTCCTATGTTTCAGCTGAGAGTGCTCAATTACCAATTTTTGATGCC
ATCTTCACTCGAATTGGTGCGGCAGATGACTTGGTATCTGGACAATCAACCTTTATGGTAGAAATGATGGAAGCAAATCA
TGCTATTTCTCAAGCAACAGAGCACTCTCTTATTCTTTTTGATGAGTTGGGAAGAGGGACAGCGACATATGATGGGATGG
CTCTTGCTCAGGCGATTATTGAATATATCCACAATCGAACAGGGGCAAAGACCCTTTTTGCCACACACTATCATGAGTTG
ACAGACTTGTCAACTAGCTTGACACAGTTAGAAAATGTTCATGTAGCAACTTTAGAAAAAGATGGGCAAGTGACCTTCCT
TCATAAGATTGAAGCTGGTCCTGCGGATAAATCTTATGGGATTCATGTGGCAAAAATTGCAGGTTTACCGAATGATTTGC
TGATGAGAGCAGACCAGATCTTAACACGATTAGAAGAACAAGCAAATGAGAAACCGTCTCTCAATCCTTCTAATAAAGGA
GCTAATGATAGTAAGGAAAATCAAGTATCTGAGCAGATATCTTTATTCACAGAAACAACTGAATCCCCTGTTTTAGAAAA
GTTACGTCAGTTGGACATCTACAACATGACCCCAATGGAAGTGATGCTAGCTGTAGCTGAGATGAAAAAACATCTCTGA

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (255-546)

• MutS domain I (MutS_I) (8-118)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

3D structure

• AlphaFold DB: U2ZHI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	76.174	100	0.762
mutS	Pseudomonas stutzeri strain ATCC 17587	37.037	100	0.376