Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HMPREF1038_RS02165 Genome accession   NC_018630
Coordinates   389730..390362 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae gamPNI0373     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 384730..395362
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF1038_RS02140 (HMPREF1038_00433) mvaD 385008..385961 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  HMPREF1038_RS02145 (HMPREF1038_00434) - 385948..386955 (+) 1008 WP_000562430.1 phosphomevalonate kinase -
  HMPREF1038_RS02150 (HMPREF1038_00435) fni 386939..387949 (+) 1011 WP_000210617.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  HMPREF1038_RS02155 (HMPREF1038_00436) liaF 388026..388724 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  HMPREF1038_RS02160 (HMPREF1038_00437) - 388721..389716 (+) 996 WP_000743661.1 sensor histidine kinase -
  HMPREF1038_RS02165 (HMPREF1038_00438) vraR 389730..390362 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  HMPREF1038_RS13375 - 390438..391132 (+) 695 Protein_415 DNA alkylation repair protein -
  HMPREF1038_RS02185 (HMPREF1038_00442) - 391282..391521 (+) 240 WP_000754501.1 hypothetical protein -
  HMPREF1038_RS02190 (HMPREF1038_00443) cbpG 391602..392192 (+) 591 Protein_417 choline-binding protein CbpG -
  HMPREF1038_RS02195 (HMPREF1038_00444) - 392494..392886 (+) 393 WP_000378125.1 tyrosine-type recombinase/integrase -
  HMPREF1038_RS02200 (HMPREF1038_00445) tig 393047..394330 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=44177 HMPREF1038_RS02165 WP_000698434.1 389730..390362(+) (vraR) [Streptococcus pneumoniae gamPNI0373]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=44177 HMPREF1038_RS02165 WP_000698434.1 389730..390362(+) (vraR) [Streptococcus pneumoniae gamPNI0373]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment