Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IQS19_RS20210 Genome accession   NZ_CP063503
Coordinates   4202798..4203457 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain EH09-18-41     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 4197798..4208457
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IQS19_RS20185 (IQS19_20190) ygiS 4199081..4200688 (-) 1608 WP_088213289.1 ABC transporter substrate-binding protein -
  IQS19_RS20190 (IQS19_20195) mqsA 4200821..4201216 (-) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  IQS19_RS20195 (IQS19_20200) mqsR 4201218..4201514 (-) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  IQS19_RS20200 (IQS19_20205) ygiV 4201719..4202201 (-) 483 WP_000183505.1 GyrI-like domain-containing protein -
  IQS19_RS20205 (IQS19_20210) ygiW 4202254..4202646 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  IQS19_RS20210 (IQS19_20215) ciaR 4202798..4203457 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  IQS19_RS20215 (IQS19_20220) qseC 4203454..4204803 (+) 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
  IQS19_RS20220 (IQS19_20225) ygiZ 4204849..4205181 (-) 333 WP_000917684.1 DUF2645 family protein -
  IQS19_RS20225 (IQS19_20230) mdaB 4205500..4206081 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  IQS19_RS20230 (IQS19_20235) ygiN 4206112..4206426 (+) 315 WP_203152255.1 putative quinol monooxygenase -
  IQS19_RS20235 (IQS19_20240) parE 4206474..4208366 (-) 1893 WP_000195292.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=440343 IQS19_RS20210 WP_001221493.1 4202798..4203457(+) (ciaR) [Escherichia coli strain EH09-18-41]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=440343 IQS19_RS20210 WP_001221493.1 4202798..4203457(+) (ciaR) [Escherichia coli strain EH09-18-41]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365