Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IQS24_RS18390 Genome accession   NZ_CP063473
Coordinates   3809205..3809864 (+) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain EM18-18-42     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3804205..3814864
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IQS24_RS18365 (IQS24_18370) ygiS 3805488..3807095 (-) 1608 WP_205595483.1 ABC transporter substrate-binding protein -
  IQS24_RS18370 (IQS24_18375) mqsA 3807228..3807623 (-) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  IQS24_RS18375 (IQS24_18380) mqsR 3807625..3807921 (-) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  IQS24_RS18380 (IQS24_18385) ygiV 3808126..3808608 (-) 483 WP_000183505.1 GyrI-like domain-containing protein -
  IQS24_RS18385 (IQS24_18390) ygiW 3808661..3809053 (-) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  IQS24_RS18390 (IQS24_18395) ciaR 3809205..3809864 (+) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  IQS24_RS18395 (IQS24_18400) qseC 3809861..3811210 (+) 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
  IQS24_RS18400 (IQS24_18405) ygiZ 3811256..3811588 (-) 333 WP_000917684.1 DUF2645 family protein -
  IQS24_RS18405 (IQS24_18410) mdaB 3811907..3812488 (+) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  IQS24_RS18410 (IQS24_18415) ygiN 3812519..3812833 (+) 315 WP_000958598.1 putative quinol monooxygenase -
  IQS24_RS18415 (IQS24_18420) parE 3812881..3814773 (-) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=439757 IQS24_RS18390 WP_001221493.1 3809205..3809864(+) (ciaR) [Escherichia coli strain EM18-18-42]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=439757 IQS24_RS18390 WP_001221493.1 3809205..3809864(+) (ciaR) [Escherichia coli strain EM18-18-42]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGTT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365