Detailed information NTG0000438

Experimentally validated

Overview

• Name: adcC
• Type: Unclear
• Locus tag: SPR_RS10080
• Genome accession: NC_003098
• Coordinates: 1968412..1969116 (-)
• Length: 234 a.a.
• NCBI ID: WP_001269474.1
• Uniprot ID: A0A0B7LF31
• Organism: Streptococcus pneumoniae R6
• Function: require for competence; Zn permease Unclear

Function

The adcCBA putative operon of Streptococcus pneumoniae, an important human pathogen, was identified in a search for transformation-deficient mutants. The addition of Zn also restored near-normal spontaneous transformation of adc mutant cells in standard transformation medium. The removal of Mn from standard transformation medium also resulted in transformation deficiency of psaA mutant cells.

Genomic Context

Location: 1963412..1974116

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPR_RS10065 (spr1974)	-	1964196..1964969 (+)	774	WP_000588546.1	DeoR/GlpR family DNA-binding transcription regulator	-
SPR_RS10070 (spr1975)	adcA	1966098..1967603 (-)	1506	WP_000724074.1	zinc ABC transporter substrate-binding lipoprotein AdcA	Unclear
SPR_RS10075 (spr1976)	adcB	1967613..1968419 (-)	807	WP_000950018.1	metal ABC transporter permease	Unclear
SPR_RS10080 (spr1977)	adcC	1968412..1969116 (-)	705	WP_001269474.1	metal ABC transporter ATP-binding protein	Unclear
SPR_RS10085 (spr1978)	adcR	1969116..1969556 (-)	441	WP_001249319.1	zinc-dependent transcriptional regulator AdcR	-
SPR_RS10090 (spr1979)	dltD	1969711..1970979 (-)	1269	WP_000919861.1	D-alanyl-lipoteichoic acid biosynthesis protein DltD	-
SPR_RS10095 (spr1980)	dltC	1970972..1971211 (-)	240	WP_000351967.1	D-alanine--poly(phosphoribitol) ligase subunit DltC	-
SPR_RS10100 (spr1981)	dltB	1971225..1972469 (-)	1245	WP_000969752.1	D-alanyl-lipoteichoic acid biosynthesis protein DltB	-
SPR_RS10105 (spr1982)	dltA	1972466..1973932 (-)	1467	WP_010976676.1	D-alanine--poly(phosphoribitol) ligase subunit DltA	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26541.95 Da
• Isoelectric Point: 7.3632

>NTDB_id=438 SPR_RS10080 WP_001269474.1 1968412..1969116(-) (adcC) [Streptococcus pneumoniae R6]
MRYITVEDLSFYYDKEPVLEHINYCVDSGEFVTLTGENGAAKTTLIKASLGILQPRIGKVAISKTNTQGKKLRIAYLPQQ
IASFNAGFPSTVYEFVKSGRYPRKGWFRRLNAHDEEHIKASLDSVGMWEHRDKRLGSLSGGQKQRAVIARMFASDPDVFI
LDEPTTGMDAGSKNEFYELMHHSAHHHGKAVLMITHDPEEVKDYADRNIHLVRNQDSPWRCFNVHENGQEVGHA

Nucleotide

• Length: 705 bp

>NTDB_id=438 SPR_RS10080 WP_001269474.1 1968412..1969116(-) (adcC) [Streptococcus pneumoniae R6]
ATGAGATATATTACGGTAGAGGATTTGTCCTTCTATTATGATAAGGAGCCTGTTCTTGAACATATCAATTATTGTGTTGA
TAGTGGGGAATTTGTTACCTTGACTGGGGAAAATGGAGCGGCTAAGACGACGCTCATCAAGGCTAGTCTTGGAATTCTGC
AACCACGCATTGGAAAGGTGGCTATTTCAAAGACAAATACGCAAGGTAAGAAATTGAGAATAGCCTATCTTCCTCAACAA
ATTGCCAGTTTTAATGCTGGTTTTCCAAGTACGGTCTATGAATTTGTCAAGTCGGGTCGCTATCCGAGAAAAGGCTGGTT
CCGTCGTTTGAATGCTCATGATGAGGAGCATATCAAGGCTAGTCTGGACTCAGTTGGCATGTGGGAACATCGAGACAAAC
GCTTGGGGTCTCTATCTGGGGGACAAAAGCAGCGAGCGGTAATTGCGCGTATGTTTGCTTCTGACCCTGATGTGTTTATC
CTAGACGAGCCGACAACGGGGATGGATGCAGGAAGTAAAAATGAATTTTACGAACTCATGCACCACAGCGCCCATCATCA
TGGCAAGGCTGTTTTGATGATTACCCATGACCCTGAAGAAGTTAAGGATTATGCGGATCGCAATATTCATCTAGTCCGTA
ACCAAGACTCGCCATGGCGTTGTTTCAATGTTCATGAGAATGGCCAGGAGGTGGGCCATGCTTAG

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (19-165)

3D structure

• AlphaFold DB: A0A0B7LF31

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
adcC	Streptococcus gordonii str. Challis substr. CH1	91.102	100	0.919

References

• [1]: A Dintilhac et al. (1997) Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Molecular Microbiology 25(4):727-39. [PMID: 9379902]