Detailed information    

experimental Experimentally validated

Overview

Name   adcB   Type   Unclear
Locus tag   SPR_RS10075 Genome accession   NC_003098
Coordinates   1967613..1968419 (-) Length   268 a.a.
NCBI ID   WP_000950018.1    Uniprot ID   O33704
Organism   Streptococcus pneumoniae R6     
Function   require for competence; Zn permease   
Unclear

Function

The adcCBA putative operon of Streptococcus pneumoniae, an important human pathogen, was identified in a search for transformation-deficient mutants.


Genomic Context

Location: 1962613..1973419
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPR_RS10060 (spr1973) - 1962617..1964020 (-) 1404 WP_000388526.1 rhamnulokinase -
  SPR_RS10065 (spr1974) - 1964196..1964969 (+) 774 WP_000588546.1 DeoR/GlpR family DNA-binding transcription regulator -
  SPR_RS10070 (spr1975) adcA 1966098..1967603 (-) 1506 WP_000724074.1 zinc ABC transporter substrate-binding lipoprotein AdcA Unclear
  SPR_RS10075 (spr1976) adcB 1967613..1968419 (-) 807 WP_000950018.1 metal ABC transporter permease Unclear
  SPR_RS10080 (spr1977) adcC 1968412..1969116 (-) 705 WP_001269474.1 metal ABC transporter ATP-binding protein Unclear
  SPR_RS10085 (spr1978) adcR 1969116..1969556 (-) 441 WP_001249319.1 zinc-dependent transcriptional regulator AdcR -
  SPR_RS10090 (spr1979) dltD 1969711..1970979 (-) 1269 WP_000919861.1 D-alanyl-lipoteichoic acid biosynthesis protein DltD -
  SPR_RS10095 (spr1980) dltC 1970972..1971211 (-) 240 WP_000351967.1 D-alanine--poly(phosphoribitol) ligase subunit DltC -
  SPR_RS10100 (spr1981) dltB 1971225..1972469 (-) 1245 WP_000969752.1 D-alanyl-lipoteichoic acid biosynthesis protein DltB -

Sequence

Protein


Download         Length: 268 a.a.        Molecular weight: 28889.90 Da        Isoelectric Point: 9.5295

>NTDB_id=437 SPR_RS10075 WP_000950018.1 1967613..1968419(-) (adcB) [Streptococcus pneumoniae R6]
MLSLLSYDFIQRAFLAVIAMSLFSPVLGTFLILRRQSLMSDTLSHVSLSGVAFGLVLGISPTVSTIAIVLIAAVFLEYLR
TVYKSFMEIGTAILMSTGLAVSLIVMSKGKSSSSMSLDQYLFGSIVTISEEQVISLFVIAAVVLILTFLFLRPMYILTFD
EDTAFVDGLPVRTMSILFNMVTGVAIALMIPAAGALLVSTIMVLPASIALRLGKNFKSVMLLASAIGFLGMVAGLYISYY
AETPASASITIIFVTVFILISLVRRFIK

Nucleotide


Download         Length: 807 bp        

>NTDB_id=437 SPR_RS10075 WP_000950018.1 1967613..1968419(-) (adcB) [Streptococcus pneumoniae R6]
ATGCTTAGTTTATTATCTTACGACTTTATACAGCGCGCCTTTTTGGCGGTTATTGCTATGAGTCTTTTCTCACCGGTATT
GGGAACCTTCCTCATCTTGCGTCGTCAGAGTTTGATGAGTGATACCCTTAGCCACGTCTCACTTTCAGGTGTAGCCTTTG
GTCTGGTTTTGGGGATTTCTCCAACTGTTTCTACTATTGCCATTGTCTTGATTGCGGCGGTCTTTCTGGAGTATCTCCGT
ACGGTTTACAAGAGCTTTATGGAAATCGGGACAGCTATCCTCATGTCAACAGGTCTGGCTGTTTCTCTGATTGTCATGAG
CAAGGGTAAAAGCTCGAGTTCAATGAGTTTGGACCAATATCTCTTTGGTTCGATCGTGACTATCAGTGAAGAACAGGTCA
TTTCCCTCTTTGTCATTGCGGCGGTTGTTTTGATTTTGACCTTTCTCTTTCTTCGTCCTATGTATATCTTAACTTTTGAC
GAAGATACGGCCTTTGTGGATGGCTTGCCAGTTCGTACCATGTCCATTCTTTTTAACATGGTGACAGGGGTGGCTATTGC
CCTTATGATTCCTGCAGCAGGAGCTCTTCTGGTATCGACCATTATGGTCTTGCCAGCTAGTATTGCCCTGCGTCTGGGGA
AAAACTTTAAATCGGTTATGCTGCTTGCCAGTGCGATTGGCTTTTTGGGAATGGTAGCAGGACTTTACATTTCCTACTAT
GCAGAAACACCTGCAAGTGCAAGTATTACCATTATTTTTGTAACTGTCTTTATACTAATCAGTTTAGTAAGACGTTTTAT
CAAATAG

Domains

Predicted by InterproScan.

ABC 3 transport family (ABC-3)

(6-263)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB O33704

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  adcB Streptococcus gordonii str. Challis substr. CH1

87.313

100

0.873

Multiple sequence alignment    



References

[1] A Dintilhac et al. (1997) Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Molecular Microbiology 25(4):727-39. [PMID: 9379902]