Detailed information    

experimental Experimentally validated

Overview

Name   adcB   Type   Unclear
Locus tag   SGO_RS09485 Genome accession   NC_009785
Coordinates   2011960..2012766 (-) Length   268 a.a.
NCBI ID   WP_012130954.1    Uniprot ID   A8AZJ3
Organism   Streptococcus gordonii str. Challis substr. CH1     
Function   require for competence   
Unclear

Function

All three mutants formed poor biofilms in a flow-cell system and were competence-defective, suggesting the adc operon plays an important role in S. gordonii biofilm formation and competence.


Genomic Context

Location: 2006960..2017766
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGO_RS09465 (SGO_1933) - 2007384..2007593 (-) 210 WP_012130950.1 heavy-metal-associated domain-containing protein -
  SGO_RS09470 (SGO_1934) - 2007614..2009860 (-) 2247 WP_080512844.1 heavy metal translocating P-type ATPase -
  SGO_RS09475 (SGO_1935) - 2009868..2010299 (-) 432 WP_012130952.1 CopY/TcrY family copper transport repressor -
  SGO_RS09480 (SGO_1936) adcA 2010448..2011950 (-) 1503 WP_012130953.1 zinc ABC transporter substrate-binding protein AdcA Unclear
  SGO_RS09485 (SGO_1937) adcB 2011960..2012766 (-) 807 WP_012130954.1 metal ABC transporter permease Unclear
  SGO_RS09490 (SGO_1938) adcC 2012759..2013469 (-) 711 WP_012130955.1 metal ABC transporter ATP-binding protein Unclear
  SGO_RS09495 (SGO_1939) - 2013466..2013909 (-) 444 WP_012130956.1 zinc-dependent MarR family transcriptional regulator -
  SGO_RS09500 (SGO_1940) - 2014527..2015669 (+) 1143 WP_012130957.1 MFS transporter -

Sequence

Protein


Download         Length: 268 a.a.        Molecular weight: 29078.21 Da        Isoelectric Point: 9.7252

>NTDB_id=434 SGO_RS09485 WP_012130954.1 2011960..2012766(-) (adcB) [Streptococcus gordonii str. Challis substr. CH1]
MLNLFSYDFMQRAFLAVIAMSLFSPILGTFLILRRQSLMSDTLSHVSLAGVAFGLVLGLSPTLTTVIVVMIAAVFLEYLR
TIYKNFMEIGTAILMSTGLAISLIVMSKGKSSSSMSLDQYLFGSIVTISTEQVISLFVIAAVVLILTFLFIRPMYILTFD
EDTAFVDGLPVRTMSILFNIVTGVAIALMIPAAGALLVSTIMVLPASIALRIGKNFKSVILLANIIGFFGMIAGLYISYY
AETPASASITIIFVSLFLVVNLIKKFVK

Nucleotide


Download         Length: 807 bp        

>NTDB_id=434 SGO_RS09485 WP_012130954.1 2011960..2012766(-) (adcB) [Streptococcus gordonii str. Challis substr. CH1]
ATGCTTAATCTATTTTCCTATGATTTTATGCAACGAGCCTTTTTGGCAGTTATTGCCATGAGTCTCTTCTCGCCGATTCT
GGGGACTTTCCTGATTTTACGTCGGCAGAGTCTCATGAGTGATACGCTTAGCCACGTTTCACTAGCAGGTGTTGCTTTTG
GCTTGGTTCTTGGTTTGTCACCAACTTTGACAACGGTGATTGTGGTCATGATAGCGGCAGTATTTTTAGAGTACTTGCGG
ACTATTTATAAGAATTTTATGGAAATCGGGACGGCCATTCTCATGTCTACTGGCTTAGCTATTTCTCTGATTGTTATGAG
TAAGGGTAAGAGTTCTAGCTCGATGAGTCTGGATCAGTATCTATTTGGCTCAATTGTGACGATTAGTACGGAGCAGGTGA
TTTCTCTCTTTGTCATTGCTGCTGTGGTGCTCATCTTAACCTTCCTCTTCATTCGGCCTATGTACATCTTGACCTTTGAT
GAGGATACGGCTTTCGTGGATGGGCTACCGGTACGGACCATGTCTATTCTCTTTAATATTGTGACGGGTGTTGCGATTGC
TCTTATGATTCCGGCTGCGGGAGCCTTGCTGGTTTCGACCATTATGGTCTTGCCGGCCAGTATTGCTCTGCGGATTGGGA
AAAACTTTAAATCGGTTATTTTGCTAGCAAATATCATCGGTTTCTTTGGTATGATTGCTGGCCTGTATATTTCTTACTAT
GCAGAGACGCCGGCAAGCGCTAGTATTACAATTATTTTCGTTAGTCTGTTTTTAGTGGTCAATTTGATCAAAAAATTTGT
GAAATAG

Domains

Predicted by InterproScan.

ABC 3 transport family (ABC-3)

(6-261)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AZJ3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  adcB Streptococcus pneumoniae R6

87.313

100

0.873

Multiple sequence alignment    



References

[1] K Mitrakul et al. (2005) Mutational analysis of the adcCBA genes in Streptococcus gordonii biofilm formation. Oral Microbiology And Immunology 20(2):122-7. [PMID: 15720574]