Detailed information    

experimental Experimentally validated

Overview

Name   adcC   Type   Unclear
Locus tag   SGO_RS09490 Genome accession   NC_009785
Coordinates   2012759..2013469 (-) Length   236 a.a.
NCBI ID   WP_012130955.1    Uniprot ID   A8AZJ4
Organism   Streptococcus gordonii str. Challis substr. CH1     
Function   require for competence   
Unclear

Function

All three mutants formed poor biofilms in a flow-cell system and were competence-defective, suggesting the adc operon plays an important role in S. gordonii biofilm formation and competence.


Genomic Context

Location: 2007759..2018469
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SGO_RS09475 (SGO_1935) - 2009868..2010299 (-) 432 WP_012130952.1 CopY/TcrY family copper transport repressor -
  SGO_RS09480 (SGO_1936) adcA 2010448..2011950 (-) 1503 WP_012130953.1 zinc ABC transporter substrate-binding protein AdcA Unclear
  SGO_RS09485 (SGO_1937) adcB 2011960..2012766 (-) 807 WP_012130954.1 metal ABC transporter permease Unclear
  SGO_RS09490 (SGO_1938) adcC 2012759..2013469 (-) 711 WP_012130955.1 metal ABC transporter ATP-binding protein Unclear
  SGO_RS09495 (SGO_1939) - 2013466..2013909 (-) 444 WP_012130956.1 zinc-dependent MarR family transcriptional regulator -
  SGO_RS09500 (SGO_1940) - 2014527..2015669 (+) 1143 WP_012130957.1 MFS transporter -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 26996.54 Da        Isoelectric Point: 8.1717

>NTDB_id=435 SGO_RS09490 WP_012130955.1 2012759..2013469(-) (adcC) [Streptococcus gordonii str. Challis substr. CH1]
MRYITVENLSFYYDKEPVLEHIHYFLDSGEFVTLTGENGAAKTTLIKASLGILQPKHGEVKISKINTQGKKLRIAYLPQQ
IASFNAGFPSTVYEFVKSGRYPRKGWFRRLNEHDEEHIKASLESVGMWEHRDKRIGSLSGGQKQRAVIARMFASDPDIFV
LDEPTTGMDAGSKDEFYKLMHHSAHKHGKAVLMITHDPEEVKKYADRNIHLVRNQDSPWRCFNVHESDNGQEVSHA

Nucleotide


Download         Length: 711 bp        

>NTDB_id=435 SGO_RS09490 WP_012130955.1 2012759..2013469(-) (adcC) [Streptococcus gordonii str. Challis substr. CH1]
ATGAGATATATAACAGTGGAAAATTTATCTTTCTACTATGATAAAGAACCTGTTTTGGAGCATATTCATTATTTTTTGGA
TAGTGGAGAGTTTGTTACGCTGACGGGGGAGAATGGAGCTGCTAAGACTACTCTGATCAAAGCTAGTCTAGGTATTTTGC
AGCCTAAGCATGGTGAGGTTAAGATTTCTAAGATAAATACTCAAGGAAAGAAATTACGTATTGCTTATCTACCTCAGCAG
ATAGCTAGTTTTAATGCTGGTTTTCCTAGTACGGTATATGAATTTGTCAAGTCAGGTCGTTATCCGCGTAAAGGTTGGTT
TCGTCGTTTGAATGAGCATGATGAAGAACATATCAAGGCAAGTCTTGAATCTGTAGGGATGTGGGAACATAGGGACAAGC
GGATTGGCTCTCTTTCTGGCGGGCAAAAGCAGAGAGCTGTGATTGCTCGGATGTTTGCTTCGGATCCGGATATTTTTGTC
CTAGATGAGCCGACAACAGGGATGGATGCAGGCAGTAAGGATGAATTTTACAAGCTCATGCACCATAGTGCTCATAAGCA
TGGAAAAGCAGTTCTGATGATTACGCACGATCCGGAAGAAGTCAAAAAGTATGCCGACCGTAATATTCATCTGGTTCGTA
ATCAGGACTCGCCTTGGCGCTGTTTCAATGTGCATGAAAGCGACAATGGACAGGAGGTGAGCCATGCTTAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(20-165)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A8AZJ4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  adcC Streptococcus pneumoniae R6

91.102

100

0.919

Multiple sequence alignment    



References

[1] K Mitrakul et al. (2005) Mutational analysis of the adcCBA genes in Streptococcus gordonii biofilm formation. Oral Microbiology And Immunology 20(2):122-7. [PMID: 15720574]