Detailed information    

experimental Experimentally validated

Overview

Name   adcA   Type   Unclear
Locus tag   SPR_RS10070 Genome accession   NC_003098
Coordinates   1966098..1967603 (-) Length   501 a.a.
NCBI ID   WP_000724074.1    Uniprot ID   Q8CWN2
Organism   Streptococcus pneumoniae R6     
Function   require for competence; Zn permease   
Unclear

Function

The adcCBA putative operon of Streptococcus pneumoniae, an important human pathogen, was identified in a search for transformation-deficient mutants.


Genomic Context

Location: 1961098..1972603
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPR_RS10050 (spr1971) - 1961412..1961852 (-) 441 WP_000912113.1 RbsD/FucU family protein -
  SPR_RS10055 (spr1972) - 1961864..1962502 (-) 639 WP_001286140.1 L-fuculose-phosphate aldolase -
  SPR_RS10060 (spr1973) - 1962617..1964020 (-) 1404 WP_000388526.1 rhamnulokinase -
  SPR_RS10065 (spr1974) - 1964196..1964969 (+) 774 WP_000588546.1 DeoR/GlpR family DNA-binding transcription regulator -
  SPR_RS10070 (spr1975) adcA 1966098..1967603 (-) 1506 WP_000724074.1 zinc ABC transporter substrate-binding lipoprotein AdcA Unclear
  SPR_RS10075 (spr1976) adcB 1967613..1968419 (-) 807 WP_000950018.1 metal ABC transporter permease Unclear
  SPR_RS10080 (spr1977) adcC 1968412..1969116 (-) 705 WP_001269474.1 metal ABC transporter ATP-binding protein Unclear
  SPR_RS10085 (spr1978) adcR 1969116..1969556 (-) 441 WP_001249319.1 zinc-dependent transcriptional regulator AdcR -
  SPR_RS10090 (spr1979) dltD 1969711..1970979 (-) 1269 WP_000919861.1 D-alanyl-lipoteichoic acid biosynthesis protein DltD -
  SPR_RS10095 (spr1980) dltC 1970972..1971211 (-) 240 WP_000351967.1 D-alanine--poly(phosphoribitol) ligase subunit DltC -
  SPR_RS10100 (spr1981) dltB 1971225..1972469 (-) 1245 WP_000969752.1 D-alanyl-lipoteichoic acid biosynthesis protein DltB -

Sequence

Protein


Download         Length: 501 a.a.        Molecular weight: 56272.04 Da        Isoelectric Point: 4.8062

>NTDB_id=436 SPR_RS10070 WP_000724074.1 1966098..1967603(-) (adcA) [Streptococcus pneumoniae R6]
MKKISLLLASLCALFLVACSNQKQADGKLNIVTTFYPVYEFTKQVAGDTANVELLIGAGTEPHEYEPSAKAVAKIQDADT
FVYENENMETWVPKLLDTLDKKKVKTIKATGDMLLLPGGEEEEGDHDHGEEGHHHEFDPHVWLSPVRAIKLVEHIRDSLS
ADYPDKKETFEKNAAAYIEKLQSLDKAYAEGLSQAKQKSFVTQHAAFNYLALDYGLKQVAISGLSPDAEPSAARLAELTE
YVKKNKIAYIYFEENASQALANTLSKEAGVKTDVLNPLESLTEEDTKAGENYISVMEKNLKALKQTTDQEGPAIEPEKAE
DTKTVQNGYFEDAAVKDRTLSDYAGNWQSVYPFLEDGTFDQVFDYKAKLTGKMTQAEYKAYYTKGYQTDVTKINITDNTM
EFVQGGQSKKYTYKYVGKKILTYKKGNRGVRFLFEATDADAGQFKYVQFSDHNIAPVKAEHFHIFFGGTSQETLFEEMDN
WPTYYPDNLSGQEIAQEMLAH

Nucleotide


Download         Length: 1506 bp        

>NTDB_id=436 SPR_RS10070 WP_000724074.1 1966098..1967603(-) (adcA) [Streptococcus pneumoniae R6]
GTGAAAAAAATTAGCTTATTACTAGCCAGTCTATGTGCCTTGTTTTTAGTGGCTTGTTCCAATCAAAAACAGGCAGATGG
TAAACTCAATATCGTGACAACCTTTTACCCTGTCTATGAATTTACCAAGCAAGTCGCAGGAGATACGGCTAATGTAGAAC
TCCTAATCGGTGCTGGGACAGAACCTCATGAATACGAACCATCTGCCAAGGCAGTTGCCAAAATCCAAGATGCAGATACC
TTCGTTTATGAAAATGAAAACATGGAAACATGGGTACCTAAATTGCTAGATACCTTGGATAAGAAAAAAGTGAAAACCAT
CAAGGCGACAGGCGATATGTTGCTCTTGCCAGGTGGCGAGGAAGAAGAGGGAGACCATGACCATGGAGAAGAAGGTCATC
ACCATGAGTTTGACCCCCATGTTTGGTTATCACCAGTTCGTGCCATTAAACTAGTAGAGCACATCCGCGACAGCTTGTCA
GCAGATTATCCTGATAAAAAAGAGACCTTTGAGAAGAATGCAGCTGCCTATATCGAAAAATTGCAATCCTTGGATAAGGC
TTACGCAGAAGGCTTGTCTCAAGCAAAACAAAAGAGCTTTGTGACTCAACACGCAGCCTTTAACTATCTTGCCTTGGACT
ATGGACTCAAACAAGTCGCAATCTCAGGCCTTTCTCCAGATGCAGAGCCATCAGCTGCTCGCTTGGCAGAATTGACAGAG
TATGTCAAGAAAAATAAAATCGCCTATATCTATTTTGAAGAAAATGCCTCACAAGCCCTTGCTAACACACTTTCAAAAGA
AGCAGGTGTCAAAACTGATGTCCTCAATCCTTTAGAAAGTCTGACAGAAGAGGACACCAAGGCTGGAGAAAACTACATTT
CCGTGATGGAGAAAAACCTCAAGGCTTTGAAACAAACAACAGACCAAGAAGGCCCAGCAATCGAACCTGAAAAGGCAGAG
GATACCAAGACAGTCCAAAATGGTTACTTCGAGGATGCAGCTGTCAAGGACCGCACCTTGAGTGACTATGCAGGTAACTG
GCAATCAGTTTATCCTTTCCTTGAAGACGGCACGTTTGACCAAGTCTTTGACTACAAGGCTAAGTTGACTGGTAAGATGA
CCCAGGCTGAGTACAAGGCTTACTATACAAAAGGCTATCAGACAGATGTGACTAAGATTAACATTACTGATAATACTATG
GAATTTGTTCAAGGTGGACAAAGCAAGAAATACACTTACAAGTATGTCGGTAAGAAAATTTTGACTTACAAGAAAGGCAA
TCGTGGCGTGCGTTTCCTCTTTGAAGCCACAGATGCTGACGCTGGACAATTCAAGTATGTTCAGTTTAGTGACCACAATA
TCGCCCCAGTTAAGGCAGAACATTTCCATATCTTTTTTGGAGGTACAAGCCAAGAAACTCTATTTGAAGAAATGGATAAT
TGGCCAACCTACTACCCAGATAACCTATCTGGCCAAGAAATCGCCCAAGAAATGTTGGCGCATTGA

Domains

Predicted by InterproScan.

ZinT (YodA) periplasmic lipocalin-like zinc-recruitment (ZinT)

(322-501)

Zinc-uptake complex component A periplasmic (ZnuA)

(31-305)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 7JJ8
  PDB 7JJ9
  PDB 7JJA
  PDB 7JJB

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  adcA Streptococcus gordonii str. Challis substr. CH1

80.639

100

0.806

Multiple sequence alignment    



References

[1] A Dintilhac et al. (1997) Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Molecular Microbiology 25(4):727-39. [PMID: 9379902]