Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IMP37_RS03430 Genome accession   NZ_CP062901
Coordinates   705791..706450 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli O152:H23 strain Res13-Lact-ER01-35     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 700791..711450
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IMP37_RS03405 (IMP37_03405) parE 700882..702774 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  IMP37_RS03410 (IMP37_03410) ygiN 702822..703136 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  IMP37_RS03415 (IMP37_03415) mdaB 703167..703748 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  IMP37_RS03420 (IMP37_03420) ygiZ 704067..704399 (+) 333 WP_000912120.1 DUF2645 family protein -
  IMP37_RS03425 (IMP37_03425) qseC 704445..705794 (-) 1350 WP_000673397.1 quorum sensing histidine kinase QseC -
  IMP37_RS03430 (IMP37_03430) ciaR 705791..706450 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  IMP37_RS03435 (IMP37_03435) ygiW 706602..706994 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  IMP37_RS03440 (IMP37_03440) ygiV 707047..707529 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  IMP37_RS03445 (IMP37_03445) mqsR 707734..708030 (+) 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR -
  IMP37_RS03450 (IMP37_03450) mqsA 708032..708427 (+) 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA -
  IMP37_RS03455 (IMP37_03455) ygiS 708560..710167 (+) 1608 WP_032283533.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=435568 IMP37_RS03430 WP_001221502.1 705791..706450(-) (ciaR) [Escherichia coli O152:H23 strain Res13-Lact-ER01-35]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=435568 IMP37_RS03430 WP_001221502.1 705791..706450(-) (ciaR) [Escherichia coli O152:H23 strain Res13-Lact-ER01-35]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365