Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IMQ31_RS17975 Genome accession   NZ_CP062824
Coordinates   3792662..3793321 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli O167:H26 strain Res13-Lact-PER13-34     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3787662..3798321
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IMQ31_RS17950 (IMQ31_17960) - 3788404..3789351 (+) 948 WP_001305988.1 iron-siderophore ABC transporter substrate-binding protein -
  IMQ31_RS17955 (IMQ31_17965) - 3789348..3790235 (+) 888 WP_000614957.1 MurR/RpiR family transcriptional regulator -
  IMQ31_RS17960 (IMQ31_17970) ygiN 3790280..3790594 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  IMQ31_RS17965 (IMQ31_17975) mdaB 3790625..3791206 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  IMQ31_RS17970 (IMQ31_17980) qseC 3791316..3792665 (-) 1350 WP_001544946.1 quorum sensing histidine kinase QseC -
  IMQ31_RS17975 (IMQ31_17985) ciaR 3792662..3793321 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  IMQ31_RS17980 (IMQ31_17990) ygiW 3793473..3793865 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  IMQ31_RS17985 (IMQ31_17995) ygiV 3793918..3794400 (+) 483 WP_024229347.1 GyrI-like domain-containing protein -
  IMQ31_RS17990 (IMQ31_18000) ygiS 3794509..3796116 (+) 1608 WP_085459056.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=434422 IMQ31_RS17975 WP_001221493.1 3792662..3793321(-) (ciaR) [Escherichia coli O167:H26 strain Res13-Lact-PER13-34]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=434422 IMQ31_RS17975 WP_001221493.1 3792662..3793321(-) (ciaR) [Escherichia coli O167:H26 strain Res13-Lact-PER13-34]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGTGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGTTAGCGGAACGTGTCGAGGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAACTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGTGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365