Detailed information NTG0043083

Bioinformatically predicted

Overview

• Name: comX
• Type: Regulator
• Locus tag: Y1U_RS00795
• Genome accession: NC_017927
• Coordinates: 140806..141303 (+)
• Length: 165 a.a.
• NCBI ID: WP_002949220.1
• Uniprot ID: Q5M6C4
• Organism: Streptococcus thermophilus MN-ZLW-002
• Function: activation of late competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 135806..146303

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Y1U_RS00775 (Y1U_C0116)	-	136669..137483 (-)	815	Protein_111	ISL3 family transposase	-
Y1U_RS00780 (Y1U_C0117)	-	137731..138057 (+)	327	WP_014607875.1	M20/M25/M40 family metallo-hydrolase	-
Y1U_RS00785 (Y1U_C0118)	-	138139..139329 (+)	1191	WP_011680651.1	SAM-dependent methyltransferase	-
Y1U_RS00790 (Y1U_C0119)	-	139588..140052 (-)	465	Protein_114	transposase family protein	-
Y1U_RS09815	-	140410..140514 (+)	105	Protein_115	IS200/IS605 family transposase	-
Y1U_RS00795 (Y1U_C0120)	comX	140806..141303 (+)	498	WP_002949220.1	sigma factor	Regulator
Y1U_RS00800 (Y1U_C0121)	-	141403..142245 (-)	843	WP_011225338.1	mechanosensitive ion channel family protein	-
Y1U_RS00805 (Y1U_C0122)	tig	142386..143669 (+)	1284	WP_011680653.1	trigger factor	-
Y1U_RS00810 (Y1U_C0123)	rpoE	143827..144402 (+)	576	WP_002949228.1	DNA-directed RNA polymerase subunit delta	-
Y1U_RS00815 (Y1U_C0124)	-	144653..146257 (+)	1605	WP_002949230.1	CTP synthase	-

Sequence

Protein

• Length: 165 a.a.
• Molecular weight: 20160.12 Da
• Isoelectric Point: 5.2073

>NTDB_id=43083 Y1U_RS00795 WP_002949220.1 140806..141303(+) (comX) [Streptococcus thermophilus MN-ZLW-002]
MEQEVFVKAYEKVRPIVLKAFRQYFIQLWDQADMEQEAMMTLYQLLKKFPDLEKDDDKLRRYFKTKFRNRLNDEVRRQES
VKRQANRQCYVEISDIAFCIPNKELDMVDRLAYDEQLNAFREQLSSEDSLKLDRLLGGECFRGRKKMIRELRFWMVDFDP
CNEED

Nucleotide

• Length: 498 bp

>NTDB_id=43083 Y1U_RS00795 WP_002949220.1 140806..141303(+) (comX) [Streptococcus thermophilus MN-ZLW-002]
ATGGAACAAGAAGTTTTTGTTAAGGCATATGAAAAGGTAAGGCCAATTGTACTTAAGGCTTTTAGGCAATACTTTATTCA
GCTTTGGGATCAAGCTGACATGGAGCAAGAGGCGATGATGACTTTGTATCAGCTTTTAAAAAAGTTTCCTGATTTAGAGA
AAGATGATGATAAGTTACGTCGTTACTTTAAAACTAAGTTTAGGAATCGACTTAATGATGAAGTGAGGCGGCAGGAGTCA
GTAAAACGTCAAGCTAATAGACAGTGCTATGTTGAAATTTCAGATATTGCCTTTTGTATTCCCAATAAGGAGCTAGATAT
GGTTGATAGACTTGCTTATGATGAACAGCTTAATGCTTTTCGTGAGCAGTTATCATCGGAAGATTCTCTTAAGTTGGATC
GATTGTTGGGTGGTGAATGCTTTAGGGGAAGGAAAAAGATGATACGAGAGTTAAGATTTTGGATGGTTGACTTTGATCCA
TGTAATGAAGAAGACTGA

Domains

Predicted by InterProScan.

• Sigma-70 region 2 (Sigma70_r2) (10-79)

3D structure

• AlphaFold DB: Q5M6C4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comX	Streptococcus thermophilus LMD-9	100	100	1
comX	Streptococcus thermophilus LMG 18311	100	100	1
comX/sigX	Streptococcus salivarius strain HSISS4	89.091	100	0.891
comX	Streptococcus salivarius SK126	88.485	100	0.885
comX	Streptococcus sobrinus strain NIDR 6715-7	41.975	98.182	0.412
comR/comR2	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comR/comR1	Streptococcus gordonii str. Challis substr. CH1	42.581	93.939	0.4
comX/sigX	Streptococcus infantarius subsp. infantarius ATCC BAA-102	41.667	94.545	0.394
comX/sigX	Streptococcus mutans UA159	41.026	94.545	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes JRS4	42.667	90.909	0.388
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS8232	42.667	90.909	0.388
comX/sigX/comX1/sigX1	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX/comX2/sigX2	Streptococcus pyogenes MGAS315	42	90.909	0.382
comX/sigX	Streptococcus suis D9	40.523	92.727	0.376
comX/sigX	Streptococcus suis isolate S10	40.523	92.727	0.376
comX/sigX	Streptococcus suis P1/7	40.523	92.727	0.376