Detailed information NTG0427093

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: G8B38_RS05005
• Genome accession: NZ_CP049694
• Coordinates: 975056..975892 (+)
• Length: 278 a.a.
• NCBI ID: WP_011017772.1
• Uniprot ID: A0A660A2Q7
• Organism: Streptococcus pyogenes strain ABC122
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 970056..980892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
G8B38_RS04975 (G8B38_05015)	-	970544..970978 (+)	435	WP_021299262.1	hypothetical protein	-
G8B38_RS04980 (G8B38_05020)	-	971028..971939 (-)	912	WP_219227143.1	diacylglycerol kinase family protein	-
G8B38_RS04985 (G8B38_05025)	-	972056..972706 (-)	651	WP_002984629.1	hemolysin III family protein	-
G8B38_RS04990 (G8B38_05030)	-	972703..973143 (-)	441	WP_011017769.1	DUF1836 domain-containing protein	-
G8B38_RS04995 (G8B38_05035)	ylqF	973362..974210 (+)	849	WP_011017770.1	ribosome biogenesis GTPase YlqF	-
G8B38_RS05000 (G8B38_05040)	-	974200..974991 (+)	792	WP_011017771.1	ribonuclease HII	-
G8B38_RS05005 (G8B38_05045)	dprA	975056..975892 (+)	837	WP_011017772.1	DNA-processing protein DprA	Machinery gene
G8B38_RS05010 (G8B38_05050)	topA	975999..978128 (+)	2130	WP_011528644.1	type I DNA topoisomerase	-
G8B38_RS05015 (G8B38_05055)	-	978204..979088 (-)	885	Protein_948	LysR family transcriptional regulator	-
G8B38_RS05020 (G8B38_05060)	-	979101..979667 (+)	567	Protein_949	PTS sugar transporter subunit IIC	-
G8B38_RS05025 (G8B38_05065)	-	979682..980674 (+)	993	WP_021299266.1	D-lactate dehydrogenase	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31088.08 Da
• Isoelectric Point: 9.0513

>NTDB_id=427093 G8B38_RS05005 WP_011017772.1 975056..975892(+) (dprA) [Streptococcus pyogenes strain ABC122]
MNHFELYKLKKAGLTNKNILNILDYQEHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=427093 G8B38_RS05005 WP_011017772.1 975056..975892(+) (dprA) [Streptococcus pyogenes strain ABC122]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAGA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTTGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

3D structure

• AlphaFold DB: A0A660A2Q7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.626	100	0.676
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.432	100	0.604
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis SK321	60.432	100	0.604
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	60.072	100	0.601
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367