Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   IGX36_RS03470 Genome accession   NZ_CP062203
Coordinates   730223..730882 (-) Length   219 a.a.
NCBI ID   WP_001221493.1    Uniprot ID   Q3YXL4
Organism   Escherichia coli strain K_EC180     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 725223..735882
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IGX36_RS03445 (IGX36_03445) - 725966..726913 (+) 948 WP_001305988.1 iron-siderophore ABC transporter substrate-binding protein -
  IGX36_RS03450 (IGX36_03450) - 726910..727797 (+) 888 WP_000614954.1 MurR/RpiR family transcriptional regulator -
  IGX36_RS03455 (IGX36_03455) ygiN 727842..728156 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  IGX36_RS03460 (IGX36_03460) mdaB 728183..728767 (-) 585 WP_192297524.1 NADPH:quinone oxidoreductase MdaB -
  IGX36_RS03465 (IGX36_03465) qseC 728877..730226 (-) 1350 WP_000673373.1 quorum sensing histidine kinase QseC -
  IGX36_RS03470 (IGX36_03470) ciaR 730223..730882 (-) 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB Regulator
  IGX36_RS03475 (IGX36_03475) ygiW 731034..731426 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  IGX36_RS03480 (IGX36_03480) ygiV 731479..731961 (+) 483 WP_000183492.1 GyrI-like domain-containing protein -
  IGX36_RS03485 (IGX36_03485) ygiS 732070..733677 (+) 1608 WP_063085111.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24687.63 Da        Isoelectric Point: 6.9850

>NTDB_id=423917 IGX36_RS03470 WP_001221493.1 730223..730882(-) (ciaR) [Escherichia coli strain K_EC180]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=423917 IGX36_RS03470 WP_001221493.1 730223..730882(-) (ciaR) [Escherichia coli strain K_EC180]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGTGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTTCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3YXL4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365