Detailed information NTG0420230

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: IB938_RS02380
• Genome accession: NZ_CP061131
• Coordinates: 446107..447459 (+)
• Length: 450 a.a.
• NCBI ID: WP_187830490.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 441107..452459

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IB938_RS02355 (IB938_02355)	-	441261..441830 (+)	570	WP_021299212.1	hypothetical protein	-
IB938_RS02360 (IB938_02360)	-	441799..442948 (+)	1150	Protein_416	acetyl-CoA C-acyltransferase	-
IB938_RS02365 (IB938_02365)	-	442905..444152 (+)	1248	WP_011528374.1	AMP-binding protein	-
IB938_RS02370 (IB938_02370)	-	444208..445242 (+)	1035	WP_011528375.1	DUF3114 domain-containing protein	-
IB938_RS02375 (IB938_02375)	yycF	445404..446114 (+)	711	WP_002985645.1	response regulator YycF	-
IB938_RS02380 (IB938_02380)	vicK	446107..447459 (+)	1353	WP_187830490.1	cell wall metabolism sensor histidine kinase VicK	Regulator
IB938_RS02385 (IB938_02385)	vicX	447463..448272 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
IB938_RS02390 (IB938_02390)	rnc	448715..449407 (+)	693	WP_002990670.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51379.76 Da
• Isoelectric Point: 5.4026

>NTDB_id=420230 IB938_RS02380 WP_187830490.1 446107..447459(+) (vicK) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDTIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=420230 IB938_RS02380 WP_187830490.1 446107..447459(+) (vicK) [Streptococcus pyogenes strain BSAC_bs1802 isolate Invasive disease]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATACAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGTTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAAGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTTT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGCTTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterProScan.

• PAS fold (PAS) (95-162)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.705	92	0.669
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64