Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   E3S77_RS00505 Genome accession   NZ_CP047797
Coordinates   92599..93228 (+) Length   209 a.a.
NCBI ID   WP_000153530.1    Uniprot ID   D9IFM7
Organism   Staphylococcus aureus strain UP_426     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 87599..98228
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  E3S77_RS00475 (E3S77_00475) - 87809..88795 (-) 987 WP_000999713.1 FUSC family protein -
  E3S77_RS00480 (E3S77_00480) - 88968..89423 (+) 456 WP_141724549.1 hypothetical protein -
  E3S77_RS00485 (E3S77_00485) map 89492..90250 (+) 759 WP_000636142.1 type I methionyl aminopeptidase -
  E3S77_RS00490 (E3S77_00490) - 90467..90853 (+) 387 WP_001110179.1 hypothetical protein -
  E3S77_RS00495 (E3S77_00495) liaF 90868..91569 (+) 702 WP_000149068.1 cell wall-active antibiotics response protein LiaF -
  E3S77_RS00500 (E3S77_00500) vraS 91566..92609 (+) 1044 WP_001017131.1 sensor histidine kinase Regulator
  E3S77_RS00505 (E3S77_00505) vraR 92599..93228 (+) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  E3S77_RS00510 (E3S77_00510) - 93341..94558 (-) 1218 WP_160195305.1 YihY/virulence factor BrkB family protein -
  E3S77_RS00515 (E3S77_00515) - 94836..95111 (-) 276 WP_000428172.1 YtxH domain-containing protein -
  E3S77_RS00520 (E3S77_00520) - 95118..95582 (-) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  E3S77_RS00525 (E3S77_00525) - 95729..95929 (+) 201 WP_000180462.1 DUF1128 family protein -
  E3S77_RS00530 (E3S77_00530) - 95932..97188 (+) 1257 WP_078103411.1 aminopeptidase -
  E3S77_RS00535 (E3S77_00535) - 97278..97808 (+) 531 WP_000184381.1 acyl-CoA thioesterase -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23545.29 Da        Isoelectric Point: 5.3889

>NTDB_id=416571 E3S77_RS00505 WP_000153530.1 92599..93228(+) (vraR) [Staphylococcus aureus strain UP_426]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=416571 E3S77_RS00505 WP_000153530.1 92599..93228(+) (vraR) [Staphylococcus aureus strain UP_426]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTAATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D9IFM7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment