Detailed information NTG0416570

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: E3S77_RS00500
• Genome accession: NZ_CP047797
• Coordinates: 91566..92609 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UP_426
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86566..97609

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
E3S77_RS00465 (E3S77_00465)	-	87068..87178 (+)	111	WP_001790257.1	hypothetical protein	-
E3S77_RS00470 (E3S77_00470)	-	87207..87620 (+)	414	WP_025174475.1	hypothetical protein	-
E3S77_RS00475 (E3S77_00475)	-	87809..88795 (-)	987	WP_000999713.1	FUSC family protein	-
E3S77_RS00480 (E3S77_00480)	-	88968..89423 (+)	456	WP_141724549.1	hypothetical protein	-
E3S77_RS00485 (E3S77_00485)	map	89492..90250 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
E3S77_RS00490 (E3S77_00490)	-	90467..90853 (+)	387	WP_001110179.1	hypothetical protein	-
E3S77_RS00495 (E3S77_00495)	liaF	90868..91569 (+)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
E3S77_RS00500 (E3S77_00500)	vraS	91566..92609 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
E3S77_RS00505 (E3S77_00505)	vraR	92599..93228 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
E3S77_RS00510 (E3S77_00510)	-	93341..94558 (-)	1218	WP_160195305.1	YihY/virulence factor BrkB family protein	-
E3S77_RS00515 (E3S77_00515)	-	94836..95111 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
E3S77_RS00520 (E3S77_00520)	-	95118..95582 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
E3S77_RS00525 (E3S77_00525)	-	95729..95929 (+)	201	WP_000180462.1	DUF1128 family protein	-
E3S77_RS00530 (E3S77_00530)	-	95932..97188 (+)	1257	WP_078103411.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=416570 E3S77_RS00500 WP_001017131.1 91566..92609(+) (vraS) [Staphylococcus aureus strain UP_426]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=416570 E3S77_RS00500 WP_001017131.1 91566..92609(+) (vraS) [Staphylococcus aureus strain UP_426]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATT
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCGGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1