Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   H7786_RS06775 Genome accession   NZ_CP060649
Coordinates   1351444..1352085 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain TSPY270     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1346444..1357085
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7786_RS06750 (H7786_06805) comFA/cflA 1346530..1347855 (-) 1326 WP_030126357.1 DEAD/DEAH box helicase Machinery gene
  H7786_RS06755 (H7786_06810) - 1347911..1348543 (+) 633 WP_030126356.1 YigZ family protein -
  H7786_RS06760 (H7786_06815) cysK 1348671..1349612 (+) 942 WP_030126355.1 cysteine synthase A -
  H7786_RS06765 (H7786_06820) - 1349630..1350007 (-) 378 WP_030126354.1 S1 RNA-binding domain-containing protein -
  H7786_RS06770 (H7786_06825) - 1350007..1351407 (-) 1401 WP_030126353.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  H7786_RS06775 (H7786_06830) vraR 1351444..1352085 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  H7786_RS06780 (H7786_06835) - 1352078..1353082 (-) 1005 WP_002991890.1 sensor histidine kinase -
  H7786_RS06785 (H7786_06840) liaF 1353079..1353771 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  H7786_RS06790 (H7786_06845) pknB 1353894..1355792 (-) 1899 WP_030126352.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  H7786_RS06795 (H7786_06850) - 1355789..1356529 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=416568 H7786_RS06775 WP_002983671.1 1351444..1352085(-) (vraR) [Streptococcus pyogenes strain TSPY270]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=416568 H7786_RS06775 WP_002983671.1 1351444..1352085(-) (vraR) [Streptococcus pyogenes strain TSPY270]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment