Detailed information NTG0413118

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H4P47_RS03770
• Genome accession: NZ_CP060075
• Coordinates: 776701..777360 (-)
• Length: 219 a.a.
• NCBI ID: WP_001221493.1
• Uniprot ID: Q3YXL4
• Organism: Escherichia coli strain G3/10
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 771701..782360

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H4P47_RS03745 (H4P47_03745)	ygiN	772602..772916 (-)	315	WP_000958596.1	putative quinol monooxygenase	-
H4P47_RS03750 (H4P47_03750)	mdaB	772947..773528 (-)	582	WP_000065430.1	NADPH:quinone oxidoreductase MdaB	-
H4P47_RS25105	-	773778..774257 (+)	480	WP_000065333.1	Hcp family type VI secretion system effector	-
H4P47_RS25110	-	774260..774970 (+)	711	WP_000834029.1	hypothetical protein	-
H4P47_RS03760 (H4P47_03760)	ygiZ	774977..775309 (+)	333	WP_000914691.1	DUF2645 family protein	-
H4P47_RS03765 (H4P47_03765)	qseC	775355..776704 (-)	1350	WP_000673402.1	quorum sensing histidine kinase QseC	-
H4P47_RS03770 (H4P47_03770)	ciaR	776701..777360 (-)	660	WP_001221493.1	quorum sensing response regulator transcription factor QseB	Regulator
H4P47_RS03775 (H4P47_03775)	ygiW	777512..777904 (+)	393	WP_000712658.1	OB fold stress tolerance protein YgiW	-
H4P47_RS03780 (H4P47_03780)	ygiV	777957..778439 (+)	483	WP_000183505.1	GyrI-like domain-containing protein	-
H4P47_RS03785 (H4P47_03785)	mqsR	778644..778940 (+)	297	WP_000415584.1	type II toxin-antitoxin system toxin MqsR	-
H4P47_RS03790 (H4P47_03790)	mqsA	778942..779337 (+)	396	WP_000650107.1	type II toxin-antitoxin system antitoxin MqsA	-
H4P47_RS03795 (H4P47_03795)	ygiS	779470..781077 (+)	1608	WP_001295629.1	ABC transporter substrate-binding protein	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24687.63 Da
• Isoelectric Point: 6.9850

>NTDB_id=413118 H4P47_RS03770 WP_001221493.1 776701..777360(-) (ciaR) [Escherichia coli strain G3/10]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide

• Length: 660 bp

>NTDB_id=413118 H4P47_RS03770 WP_001221493.1 776701..777360(-) (ciaR) [Escherichia coli strain G3/10]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-216)

• Response regulator receiver domain (Response_reg) (3-112)

3D structure

• AlphaFold DB: Q3YXL4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	38.326	100	0.397
ciaR	Streptococcus pneumoniae D39	38.326	100	0.397
ciaR	Streptococcus pneumoniae R6	38.326	100	0.397
ciaR	Streptococcus pneumoniae TIGR4	38.326	100	0.397
ciaR	Streptococcus mutans UA159	35.874	100	0.365