Detailed information NTG0410734

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: GQ677_RS03745
• Genome accession: NZ_CP047120
• Coordinates: 720936..721973 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain 1085
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 715936..726973

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GQ677_RS03720 (GQ677_03720)	-	716200..717531 (+)	1332	WP_136273999.1	dipeptidase	-
GQ677_RS03725 (GQ677_03725)	arcC	717551..718501 (+)	951	WP_009880962.1	carbamate kinase	-
GQ677_RS03730 (GQ677_03730)	asnA	718814..719806 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
GQ677_RS03735 (GQ677_03735)	rsmD	719929..720468 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
GQ677_RS03740 (GQ677_03740)	coaD	720458..720949 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
GQ677_RS03745 (GQ677_03745)	sepM	720936..721973 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
GQ677_RS03750 (GQ677_03750)	-	722378..723355 (+)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
GQ677_RS03755 (GQ677_03755)	-	723803..724423 (+)	621	WP_002992791.1	YutD family protein	-
GQ677_RS03760 (GQ677_03760)	rlmN	724427..725506 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
GQ677_RS03765 (GQ677_03765)	-	725588..726214 (-)	627	WP_002983834.1	A24 family peptidase	-
GQ677_RS03770 (GQ677_03770)	-	726442..726969 (+)	528	WP_002983837.1	Dps family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=410734 GQ677_RS03745 WP_010922499.1 720936..721973(+) (sepM) [Streptococcus pyogenes strain 1085]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=410734 GQ677_RS03745 WP_010922499.1 720936..721973(+) (sepM) [Streptococcus pyogenes strain 1085]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAG

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693