Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HZS87_RS18660 Genome accession   NZ_CP058725
Coordinates   3824266..3824925 (-) Length   219 a.a.
NCBI ID   WP_001221502.1    Uniprot ID   B7LGG8
Organism   Escherichia coli strain S171-1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 3819266..3829925
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HZS87_RS18635 parE 3819357..3821249 (+) 1893 WP_000195296.1 DNA topoisomerase IV subunit B -
  HZS87_RS18640 ygiN 3821297..3821611 (-) 315 WP_000958598.1 putative quinol monooxygenase -
  HZS87_RS18645 mdaB 3821642..3822223 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  HZS87_RS18650 ygiZ 3822542..3822874 (+) 333 WP_000912120.1 DUF2645 family protein -
  HZS87_RS18655 qseC 3822920..3824269 (-) 1350 WP_000673354.1 quorum sensing histidine kinase QseC -
  HZS87_RS18660 ciaR 3824266..3824925 (-) 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB Regulator
  HZS87_RS18665 ygiW 3825077..3825469 (+) 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
  HZS87_RS18670 ygiV 3825522..3826004 (+) 483 WP_000183494.1 GyrI-like domain-containing protein -
  HZS87_RS18675 parC 3826550..3828808 (+) 2259 WP_024249834.1 DNA topoisomerase IV subunit A -
  HZS87_RS18680 plsC 3829042..3829779 (+) 738 WP_000965712.1 1-acylglycerol-3-phosphate O-acyltransferase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24745.66 Da        Isoelectric Point: 6.6543

>NTDB_id=406891 HZS87_RS18660 WP_001221502.1 3824266..3824925(-) (ciaR) [Escherichia coli strain S171-1]
MRILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALEERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=406891 HZS87_RS18660 WP_001221502.1 3824266..3824925(-) (ciaR) [Escherichia coli strain S171-1]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTAGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTTTATAGCGCGCCTTATGATGCGGTGATCCTGGATTTAACCT
TACCAGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTACTGATCCTGACCGCG
CGCGATGCGCTGGAGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGTAACGTCATGC
TCGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACACTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGTAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)

Response regulator receiver domain (Response_reg)

(3-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B7LGG8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365