Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   HYE75_RS03870 Genome accession   NZ_CP058596
Coordinates   791529..792188 (-) Length   219 a.a.
NCBI ID   WP_001221477.1    Uniprot ID   A0A0H2VCI3
Organism   Escherichia coli strain UPEC_U013     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 786529..797188
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HYE75_RS03845 (HYE75_03840) ygiN 787430..787744 (-) 315 WP_000633738.1 putative quinol monooxygenase -
  HYE75_RS03850 (HYE75_03845) mdaB 787775..788356 (-) 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
  HYE75_RS25215 - 788606..789085 (+) 480 WP_000069056.1 Hcp family type VI secretion system effector -
  HYE75_RS25220 - 789088..789798 (+) 711 WP_000834021.1 hypothetical protein -
  HYE75_RS03860 (HYE75_03855) ygiZ 789805..790137 (+) 333 WP_000914696.1 DUF2645 family protein -
  HYE75_RS03865 (HYE75_03860) qseC 790183..791532 (-) 1350 WP_000673390.1 quorum sensing histidine kinase QseC -
  HYE75_RS03870 (HYE75_03865) ciaR 791529..792188 (-) 660 WP_001221477.1 quorum sensing response regulator transcription factor QseB Regulator
  HYE75_RS03875 (HYE75_03870) ygiW 792340..792732 (+) 393 WP_000712665.1 OB fold stress tolerance protein YgiW -
  HYE75_RS03880 (HYE75_03875) ygiV 792785..793267 (+) 483 WP_000183488.1 GyrI-like domain-containing protein -
  HYE75_RS03885 (HYE75_03880) ygiS 793376..794983 (+) 1608 WP_001305104.1 ABC transporter substrate-binding protein -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24756.74 Da        Isoelectric Point: 7.4218

>NTDB_id=405736 HYE75_RS03870 WP_001221477.1 791529..792188(-) (ciaR) [Escherichia coli strain UPEC_U013]
MRILLIEDDMLIGDGIKTGLSKMGFRVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA
RDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQASNELRHGNVMLDPGKRIATLAGEPLTLKPKEFALLEL
LMRNAGRVLPRKLIEEKLYTWDEEVTSNAVEVHVHHLRRKLGSDFIRTVHGIGYTLGEK

Nucleotide


Download         Length: 660 bp        

>NTDB_id=405736 HYE75_RS03870 WP_001221477.1 791529..792188(-) (ciaR) [Escherichia coli strain UPEC_U013]
ATGCGAATTTTACTGATAGAAGATGACATGCTGATTGGCGACGGCATCAAAACGGGCCTTAGTAAAATGGGTTTTCGCGT
CGACTGGTTTACACAAGGTCGTCAGGGAAAAGAGGCGCTATATAGCGCACCTTATGATGCGGTGATCCTGGATTTAACCT
TACCGGGCATGGATGGTCGCGATATTTTGCGCGAATGGCGAGAAAAAGGTCAGCGTGAGCCGGTATTGATCCTGACTGCG
CGCGATGCGCTGGCGGAACGTGTAGAAGGGCTGCGTCTGGGAGCTGACGATTATCTGTGTAAACCTTTTGCGTTGATAGA
AGTCGCCGCCAGGCTGGAAGCTCTGATGCGCCGAACCAACGGCCAGGCCAGCAACGAGCTGCGCCACGGCAACGTCATGC
TAGACCCCGGCAAACGTATCGCCACGCTGGCTGGCGAACCCTTAACGCTGAAACCAAAAGAATTTGCCCTGCTGGAATTA
CTGATGCGTAACGCTGGTCGGGTACTGCCGCGCAAACTGATTGAAGAGAAACTGTATACCTGGGACGAAGAGGTCACCAG
TAATGCCGTTGAAGTGCATGTGCATCATCTGCGACGCAAACTCGGCAGTGATTTTATTCGTACCGTGCATGGTATTGGCT
ACACATTAGGTGAGAAATGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-216)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2VCI3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

38.326

100

0.397
  ciaR Streptococcus pneumoniae D39

38.326

100

0.397
  ciaR Streptococcus pneumoniae R6

38.326

100

0.397
  ciaR Streptococcus pneumoniae TIGR4

38.326

100

0.397
  ciaR Streptococcus mutans UA159

35.874

100

0.365